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Inhibition of Cell Aggregation by Antibodies directed against Actomyosin

Abstract

IT has been proposed that cell adhesion involves the participation of actomyosin-like protein located in the surface1. The theory was based mainly on the similarity between actomyosin proteins in muscle2–5 and non-muscle cells6–8, a comparison of the properties of actomyosin protein with the effects of calcium and of nucleoside phosphates9–11 on cell aggregation, and evidence indicating the presence of actomyosin-like protein at the surface of liver cells12–15. Hypothetical models have been suggested for the involvement of contractile actomyosin in inter-molecular bonding between adjacent cells16–18.

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JONES, B., KEMP, R. & GRÖSCHEL-STEWART, U. Inhibition of Cell Aggregation by Antibodies directed against Actomyosin. Nature 226, 261–262 (1970). https://doi.org/10.1038/226261a0

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