Abstract
PREPARATIONS of adipose tissue from obese hyperglycaemic mice of the C57B1/6J-ob strain have a reduced sensitivity to the fatty acid mobilizing activity of epinephrine1. Epinephrine is believed to exert its lipolytic effect by increasing the production of cyclic AMP2. This activates 
the “hormone sensitive” lipase3 resulting in triglyceride breakdown. The cyclic AMP is then destroyed by 3′,5′-nucleotide phosphodiesterase4 which can be inhibited by caffeine or theophylline. The site at which this pathway is altered in obese mice is not known. Although the concentration of lipase is reduced in adipose tissue from obese mice5, this is more than compensated by the extra adipose tissue in these mice, and cannot account for the cold sensitivity of these animals, which is attributed to the failure to mobilize fat6. We have investigated the pathway controlling the mobilization of fatty acids from epididymal fat pads in order to determine the rate limiting step in the obese mice.
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ENSER, M. Fatty Acid Mobilization in Obese Mice. Nature 226, 175–177 (1970). https://doi.org/10.1038/226175b0
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DOI: https://doi.org/10.1038/226175b0
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