Abstract
Cohen, Marinello and Back1 (1967) first reported that lysergic acid diethylamide (LSD) increased chromosome abnormalities in human leucocytes. Although some later work failed to support this observation2–4, others have confirmed that LSD damages chromosomes5–10. I have investigated the dose–effect relationship of LSD and the type of damage produced in chromosomes of leucocyte cultures of the marsupial Potorous tridactylus (rat-kangaroo), which has a few large chromosomes (2 n = 12 in ♀ and 13 in ♂) that make scoring of damage relatively easy and accurate.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Cohen, M. M., Marinello, M. J., and Back, N., Science, 155, 1417 (1967).
Longhman, W. D., Sargent, T. W., and Israelstam, D. M., Science, 158, 508 (1967).
Sato, H., and Pergament, E., Lancet, i, 639 (1968).
Sparks, R. S., Melnyk, J., and Bozzetti, L. P., Science, 160, 1343 (1968).
Cohen, M. M., Hirschhorn, K., and Frosch, W. A., New Engl. J. Med., 277, 1043 (1967).
Cohen, M. M., and Mukerjee, A. B., Nature, 219, 1972 (1968).
Egozcue, J., Irwin, S., and Muruffo, C. A., J. Amer. Med. Assoc., 204, 214 (1968).
Irwin, S., and Egozcue, J., Science, 157, 313 (1967).
Jarvik, L. F., and Kato, T., Lancet, i, 250 (1968).
Zellweger, H., MacDonald, J. S., and Abbo, G., Lancet, ii, 1066 (1967).
Clark, A. M., Nature, 183, 731 (1959).
Clark, A. M., Z. Vererbungsl., 91, 74 (1960).
Clark, A. M., Z. Vererbungsl., 94, 115 (1963).
Brink, N. G., Z. Vererbungsl., 94, 331 (1963).
Avanzi, S., Caryologia, 14, 251 (1961).
Avanzi, S., Caryologia, 15, 351 (1962).
Bick, Y. A. E., and Jackson, W. D., Austral. J. Biol. Sci., 21, 469 (1967).
Indanpaan-Heikkila, J. E., and Schoolar, J. C., Science, 164, 1295 (1967).
Schoental, R., and Magee, P. N., J. Pathol. Bact., 78, 471 (1959).
Alexander, J. J., Miles, B. E., Gold, G. M., and Alexander, R. B., Science, 157, 459 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BICK, Y. Comparison of the Effects of LSD, Heliotrine and X-irradiation on Chromosome Breakage, and the Effects of LSD on the Rate of Cell Division. Nature 226, 1165–1167 (1970). https://doi.org/10.1038/2261165a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/2261165a0
This article is cited by
-
Ploidy effect on the radiation reaction of mammalian cells
Human Genetics (1974)
-
LSD-25 Does Not Intercalate in DNA
Nature (1971)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.