Abstract
IT is well known that L-asparaginase (L-asparagine amidohydrolase, EC 3.5.1.1) is the antitumour agent in guineapig serum1. The same antitumour activity has been demonstrated for the L-asparaginase from Escherichia coli2 and recently for that from Erwinia carotovora3. L-Asparaginase preparations from other bacteria2,4 or yeast5 have no inhibitory action. After screening a number of microorganisms, a strain of Aspergillus terreus which produces an L-asparaginase active against Walker 256 ascites carcinosarcoma6 has now been isolated.
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DE-ANGELI, L., POCCHIARI, F., RUSSI, S. et al. Effect of L-Asparaginase from Aspergillus terreus on Ascites Sarcoma in the Rat. Nature 225, 549–550 (1970). https://doi.org/10.1038/225549a0
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DOI: https://doi.org/10.1038/225549a0
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