Abstract
TETRAPARENTAL mice are produced by fusing two eight-cell stage embryos. If the two embryos originate from different inbred strains, allelic differences between the strains produce mosaic patterns in the adult tetraparental which make possible inferences about development1–3. Mintz and Baker have elegantly used this concept to confirm that somatic muscle cells fuse during development4. They used an isozyme variant of isocitrate dehydrogenase, and found hybrid enzyme patterns in somatic muscle tissue. Only parental patterns were demonstrable in other tissues, such as the liver.
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References
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WEGMANN, T. Enzyme Patterns in Tetraparental Mouse Liver. Nature 225, 462–463 (1970). https://doi.org/10.1038/225462a0
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DOI: https://doi.org/10.1038/225462a0
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