Abstract
A CLUE to the structure of macromolecules in solution is given by the exchange of protons between the macromolecules and the surrounding solvent. We have investigated the exchange of tritium between DNA and water at different temperatures. We have used the technique of ‘Sephadex’ chromatography described by Englander1 and used by Printz and von Hippel2 to study tritium exchange between DNA and water.
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References
Englander, S. W., Biochemistry, 2, 798 (1963).
Printz, M. P., and von Hippel, P. H., Proc. US Nat. Acad. Sci., 53, 363 (1963).
Lark, K. G., Repko, T., and Hoffman, E. J., Biochim. Biophys. Acta, 76, 9 (1963).
Eigen, M., in Nobel Symposium 5: Fast Reactions and Primary Processes in Chemical Kinetics (edit. by Claesson, S.) (Interscience Publishers, NY, 1967).
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BIRD, R., LARK, K., CURNUTTE, B. et al. Exchange of Bound Tritium between DNA and Water at Different Temperatures. Nature 225, 1043–1045 (1970). https://doi.org/10.1038/2251043a0
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DOI: https://doi.org/10.1038/2251043a0
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