Abstract
WHEN Escherichia coli is infected with T-even bacteriophage, host nucleic acid and protein synthesis cease abruptly. A burst of RNA synthesis from viral DNA template then occurs. The viral RNA is subsequently utilized by the host machinery to produce phage-specific proteins1–3. Little is known, however, of the mechanism of the switch-over from host to viral function.
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References
Cohen, S. S., J. Biol. Chem., 174, 281 (1948).
Volkin, E., and Astrachan, L., Virology, 2, 149 (1956).
Astrachan, L., and Volkin, E., Biochim. Biophys. Acta, 29, 536 (1958).
Hershey, A. D., and Chase, M., J. Gen. Physiol., 36, 39 (1952).
Pardee, A. B., and Prestidge, L. S., Biochim. Biophys. Acta, 49, 77 (1961).
Kaempfer, R. O. R., and Magasanik, B., J. Mol. Biol., 27, 495 (1967).
Okamoto, K., Sugino, Y., and Nomura, M., J. Mol. Biol., 5, 527 (1962).
Hershey, A. D., Dixon, J., and Chase, M., J. Gen. Physiol., 36, 777 (1953)
Stone, A. B., and Burton, K., Biochem. J., 85, 600 (1962).
Oleson, A. E., and Koerner, J. F., J. Biol. Chem., 239, 2935 (1964).
So, A. G., Davie, E. W., Epstein, R., and Tissières, A., Proc. US Nat. Acad. Sci., 58, 1739 (1967).
McCarthy, B. J., and McConaughy, B. L., Biochem. Genet., 2, 37 (1968).
McConaughy, B. L., Laird, C. D., and McCarthy, B. J., Biochemistry, 8, 3289 (1969).
Cheong, L. C. Y., and Chargaff, E., Nature, 221, 1144 (1969).
Walter, G., Seifert, W., and Zilling, W., Biochem. Biophys. Res. Commun., 30, 240 (1968).
Bautz, E. K. F., and Dunn, J. J., Biochem. Biophys. Res. Commun., 34, 230 (1969).
Geiduschek, E. P., and Sklar, J., Nature, 221, 833 (1969).
Haselkorn, R., Vogel, M., and Brown, R. D., Nature, 221, 836 (1969).
Crouch, R. J., Hall, B. D., and Hager, G., Nature, 223, 476 (1969).
Bolle, A., Epstein, R., Salser, W., and Geiduschek, E. P., J. Mol. Biol., 31, 325 (1968).
Marmur, J., J. Mol. Biol., 3, 208 (1961).
Chamberlin, M., and Berg, P., Proc. US Nat. Acad. Sci., 48, 81 (1962).
Richardson, J. P., Proc. US Nat. Acad. Sci., 55, 1616 (1966).
Burgess, R. R., Dunn, J. J., and Bautz, E. K. F., Nature, 221, 43 (1969).
Travers, A. A., and Burgess, R. R., Nature, 222, 537 (1969).
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Su, S., WEINBERG, F., So, A. et al. RNA Polymerase and the Shut-off of Host RNA and Protein Synthesis in T4 Phage Infection. Nature 225, 62–63 (1970). https://doi.org/10.1038/225062a0
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DOI: https://doi.org/10.1038/225062a0
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