Abstract
HOUSEFLIES metabolize dialkyl phosphorothionate insecticides, such as diazinon and parathion, to the corresponding dialkyl phosphorothioic acids1,2. This reaction is thought to be controlled by gene a, on chromosome II (ref. 3), associated with low aliesterase activity4. The cleavage mechanism is reported to be in the microsomes2,5,6. I have found three detoxification mechanisms in subcellular fractions of six strains (Table 1) of housefly and related these to the genetics of diazinon-resistance7,8 of the flies.
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References
Matsumura, F., and Hogendijk, C. J., J. Agric. Food Chem., 12, 447 (1964).
Nakatsugawa, T., Tolman, N. M., and Dahm, P. A., J. Econ. Ent., 62, 408 (1969).
Wagoner, D. E., Genetics (Princeton), 57, 729 (1967).
Oppenoorth, F. J., Ent. Exp. Appl., 2, 304 (1959).
Nakatsugawa, T., and Dahm, P. A., Biochem. Pharmacol., 17, 1577 (1968).
Fukami, J., and Shishido, T., J. Econ. Ent., 59, 1338 (1966).
Sawicki, R. M., and Farnham, A. W., Bull. Ent. Res. (in the press).
Sawicki, R. M., and Farnham, A. W., Ent. Exp. Appl., 10, 363 (1967).
Gwiazda, M., and Lord, K. A., Ann. Appl. Biol., 59, 221 (1967).
Hollingworth, R. M., Metcalf, R. L., and Fukuto, T. R., J. Agric. Fd. Chem., 15, 242 (1967).
ElBasheir, S., and Oppenoorth, F. J., Nature, 223, 210 (1969).
Oppenoorth, F. J., and van Asperen, K., Ent. Exp. Appl., 4, 311 (1961).
Bell, J. D., Bull. Ent. Res., 58, 137 (1968).
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LEWIS, J. Detoxification of Diazinon by Subcellular Fractions of Diazinon-resistant and Susceptible Houseflies. Nature 224, 917–918 (1969). https://doi.org/10.1038/224917a0
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DOI: https://doi.org/10.1038/224917a0
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