Abstract
A COMMON drawback associated with the use of antineoplastic and immunosuppressive drugs is an increased susceptibility to infection1–4. This can be attributed, at least in part, to leucopenia5,6, hypogammaglobulinaemia7 and impairments of the normal processes of phagocytosis8 and the primary antibody response9–11. It was recently demonstrated that the antineoplastic agent cyclophosphamide depresses the production of interferon12 and causes higher peak titres of EMC virus in the mouse13, thus producing a striking increase in mortality. We now report that treatment of rats with Cyclophosphamide produces a rapidly increasing bacteriaemia together with significant bacterial proliferation within various organs following experimental infection with Staphylococcus aureus.
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References
Hill, R. B., Rowlands, D. T., and Rifkind, D., New Engl. J. Med., 271, 1021 (1964).
Hutter, R. V. P., and Collins, H. S., Lab. Invest., 11, 1035 (1962).
Sidransky, H., Verney, E., and Beede, H., Arch. Path., 79, 299 (1965).
Rifkind, D., Marchioro, T. L., Waddell, W., and Starzl, T., J. Amer. Med. Ass., 189, 397 (1964).
Kahri, A. I., Salmi, A., and Hannuksela, M., Acta Path. Microbiol. Scand., 64, 441 (1965).
Wheeler, A. G., Dansby, D., Hawkins, H. C., Payne, H. G., and Weikel, J. H., Toxicol. Appl. Pharm., 4, 324 (1962).
Mackiewicz, U., Acta Polon. Pharm., 24, 551 (1967).
Megirian, R., J. Reticuloendothelial Soc., 2, 238 (1965).
Groves, D. A., Canad. J. Med. Tech., 29, 33 (1967).
Finder, H., Z. Ges. Exp. Med., 143, 105 (1967).
Leven, R., New Engl. J. Med., 271, 16 (1964).
Robinson, T. W. E., and Heath, R. B., Nature, 217, 178 (1968).
Murphy, B. R., and Glasgow, L. A., Anti. Agents and Chemotherapy, 661 (1967).
Hiatt, N., Warner, N. E., and Furman, G., Surgery, 61, 596 (1967).
Fox, M., Transplantation, 2, 475 (1964).
Smith, J. M., and Dubos, R. J., J. Exp. Med., 103, 87 (1956).
Prokopowicz, J., Rejniak, L., and Niewiarowski, S., Experientia, 23, 813 (1967).
Stachura, J., Papla, B., and Dubiel-Bigaj, M., Acta Med. Polor., 9, 319 (1968).
Hirch, J. G., and Cohn, Z. A., J. Exp. Med., 112, 1005 (1960).
Selvaraj, R. J., and Sbarra, A. J., J. Bacteriol., 94, 149 (1967).
McRipley, R. J., and Sbarra, A. J., J. Bacteriol., 94, 1425 (1967).
Evans, W. H., and Rechcigl, M., Biochim. Biophys. Acta, 148, 243 (1967).
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SHARBAUGH, R., GROGAN, J. Effect of Cyclophosphamide on Experimental Staphylococcus Infection in the Rat. Nature 224, 809–810 (1969). https://doi.org/10.1038/224809a0
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DOI: https://doi.org/10.1038/224809a0
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