Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Inhibitory Effect of a Synthetic Interferon Inducer on Murine Sarcoma and Leukaemia Virus Infection in vitro

Nature volume 224, pages 604–605 (1969)Cite this article

Abstract

SYNTHETIC polyribonucleotide complexes stimulate the synthesis of host interferon in vivo and in vitro1–4. The protective effect of polyinosinic.polycytidylic RNA (poly I.poly C) on virus infection in vivo and in vitro has been described (refs. 1–5 and personal communication from N. B. Finter). Poly I.poly C was reported to suppress the growth of transplantable murine tumours of known or unknown viral aetiology6,7. We have recently described the inhibitory effect of poly I.poly C on the induction of sarcomas in newborn mice by the murine sarcoma virus (MSV)2,3.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Field, A. K., Tytell, A. A., Lampson, G. P., and Hilleman, M. R., Proc. US Nat. Acad. Sci., 58, 1004 (1967).

    Article  CAS  ADS  Google Scholar 

  2. Sarma, P. S., Shiu, G., Neubauer, R., Baron, S., and Huebner, R. J., Proc. US Nat. Acad. Sci., 62, 1046 (1969).

    Article  CAS  ADS  Google Scholar 

  3. Baron, S., DuBoy, H., Bucker, C. E., Johnson, M. C., Park, J., Billiau, J., Sarma, P. S., and Huebner, R. J., Ann. NY Acad. Sci. (in the press).

  4. Dianzani, F., Rita, G., Cantagalli, P., and Gagnoni, S., J. Immunol., 102, 24 (1969).

    CAS  PubMed  Google Scholar 

  5. Park, J. H., and Baron, S., Science, 162, 811 (1968).

    Article  CAS  ADS  Google Scholar 

  6. Levy, H. B., Law, L. W., and Rabson, A. S., Proc. US Nat. Acad. Sci., 62, 357 (1969).

    Article  CAS  ADS  Google Scholar 

  7. Zeleznick, L. D., and Bhuyan, B. K., Proc. Soc. Exp. Biol. and Med., 130, 126 (1969).

    Article  CAS  Google Scholar 

  8. Rhim, J. S., Greenawalt, C., and Huebner, R. J., Nature, 222, 1166 (1969).

    Article  CAS  ADS  Google Scholar 

  9. Sarma, P. S., Cheong, M. P., Hartley, J. W., and Huebner, R. J., Virology, 33, 180 (1967).

    Article  CAS  Google Scholar 

  10. Sarma, P. S., Shiu, G., Baron, S., and Huebner, R. J., Nature, 223, 845 (1969).

    Article  CAS  ADS  Google Scholar 

  11. Hartley, J. W., and Rowe, W. P., Proc. US Nat. Acad. Sci., 55, 780 (1966).

    Article  CAS  ADS  Google Scholar 

  12. Hartley, J. W., Rowe, W. P., Capps, W. I., and Huebner, R. J., J. Virol., 3, 126 (1969).

    Article  CAS  Google Scholar 

  13. Gresser, I., Fontaine, D., Coppey, J., Falcoff, R., and Falcoff, E., Proc. Soc. Exp. Biol. and Med., 124, 84 (1967).

    Article  CAS  Google Scholar 

  14. Peries, J., Canivet, M., Guillemain, G., and Boiron, M., J. Gen. Virol., 3, 465 (1968).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Institutes of Health,

    PADMAN S. SARMA, SAMUEL BARON & ROBERT J. HUEBNER

  2. Microbiological Associates, Inc., Bethesda, Maryland, 20014

    GRACE SHIU

Authors
  1. PADMAN S. SARMA
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. SAMUEL BARON
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. ROBERT J. HUEBNER
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. GRACE SHIU
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SARMA, P., BARON, S., HUEBNER, R. et al. Inhibitory Effect of a Synthetic Interferon Inducer on Murine Sarcoma and Leukaemia Virus Infection in vitro. Nature 224, 604–605 (1969). https://doi.org/10.1038/224604a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/224604a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing