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Metal-dependent Aggregation of Biogenic Amines: A Hypothesis for their Storage and Release

Nature volume 224, pages 281–283 (1969)Cite this article

Abstract

5-HYDROXYTRYPTAMINE and adenosine triphosphate (ATP) form aggregates of high apparent molecular weight in the storage organelles (“dense bodies”) of blood platelets of rabbits as well as in artificial mixtures of the two constituents1,2. We now present evidence that aggregation may be a general principle for the storage of biogenic amines and that alkaline–earth metals are able to enhance or reduce aggregation.

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Authors and Affiliations

  1. Research Department, F. Hoffmann–La Roche and Co. Ltd, Basle, Switzerland

    K. H. BERNEIS, A. PLETSCHER & M. DA PRADA

Authors
  1. K. H. BERNEIS
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  2. A. PLETSCHER
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  3. M. DA PRADA
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BERNEIS, K., PLETSCHER, A. & DA PRADA, M. Metal-dependent Aggregation of Biogenic Amines: A Hypothesis for their Storage and Release. Nature 224, 281–283 (1969). https://doi.org/10.1038/224281a0

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  • DOI: https://doi.org/10.1038/224281a0

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