Abstract
GENETIC information for the human HL–A transplantation antigens seems to be located at two closely linked mutational sites, which are often called LA, and Four1. A considerable number of genetic factors, behaving as multiple alleles, belong to each of the two sites1–4. It is still uncertain whether these are separate but closely linked “genetic units”, or whether tney belong to the same “unit” as families with unequivocal recombinants. Batchelor and Chapman5 and Ward et al.6 found a few cross-overs, but they were questioned by Walford7, for they did not relate to well known HL–A specificities.
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References
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KISSMEYER-NIELSEN, F., SVEJGAARD, A., AHRONS, S. et al. Crossing-over within the HL–A System. Nature 224, 75–76 (1969). https://doi.org/10.1038/224075a0
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DOI: https://doi.org/10.1038/224075a0
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