Abstract
The quinone methide intermediate could be the characteristic species for a beta adrenergic agonist. For the alpha adrenergic agonists the characteristic catecholamine seems to be an aziridine, an internally cyclized quinone methide derivative.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Belleau, B., in Adrenergic Mechanisms (edit. by Vane, J. R., Wolstenholme, G. E. W., and O'Connor, M.), 223 (Little, Brown, Boston, 1960).
Belleau, B., in Modern Concepts in the Relationship between Structure and Pharmacological Activity (edit. by Brunings, K. J., and Lindgren, P.), 75 (Pergamon Press, Oxford, 1963).
Belleau, B., Ann. NY Acad. Sci., 139, 580 (1967).
Belleau, B., Pharmacol. Rev., 18, 131 (1966).
Triggle, D. J., in Advances in Drug Research (edit. by Harper, N. J., and Simmonds, A. B.), II, 173 (Academic Press, London and New York, 1965).
Bloom, B. M., and Goldman, I. M., in Advances in Drug Research (edit. by Harper, N. J., and Simmonds, A. B.), III, 121 (Academic Press, London and New York, 1966).
Chapman, N. B., and Graham, J. D. P., in Drugs Affecting the Peripheral Nervous System (edit. by Burger, A.), I, 473 (Dekker, New York, 1967).
Furchgott, R. F., Ann. NY Acad. Sci., 139, 553 (1967).
Ariëns, E. J., Ann. NY Acad. Sci., 139, 606 (1967).
Ahlquist, R. P., Amer. J. Physiol., 153, 586 (1948).
Ahlquist, R. P., Arch. Intern. Pharmacodynam. Ther., 139, 38 (1962).
Lands, A. M., and Brown, jun., T. G., in Drugs Affecting the Peripheral Nervous System (edit. by Burger, A.), I, 339 (Dekker, New York, 1967).
Larsen, A. A., Gould, W. A., Roth, H. R., Comer, W. T., Uloth, R. H., Dungan, K. W., and Lish, P. M., J. Med. Chem., 10, 462 (1967).
Dungan, K. W., Cho, Y. W., Gomoll, A. W., Aviado, D. M., and Lish, P. M., J. Pharmacol. Exp. Ther., 164, 290 (1968).
Hartley, D., Jack, D., Lunts, L. H. C., and Ritchie, A. C., Nature, 219, 861 (1968).
Brittain, R. T., Farmer, J. B., Jack, D., Martin, L. E., and Simpson, W. T., Nature, 219, 862 (1968).
Scriabine, A., Moore, P. F., Iorio, L. C., Goldman, I. M., McShane, W. K., and Booher, K. D., J. Pharmacol. Exp. Ther., 162, 60 (1968).
Iwasawa, Y., and Kiyomoto, A., Japan. J. Pharmacol., 17, 143 (1967).
Turner, A. B., Quart. Rev. (London), 18, 347 (1964).
Tullar, B. F., J. Amer. Chem. Soc., 70, 2067 (1948).
Tiguchi, T., and Schroeter, L. C., J. Amer. Chem. Soc., 82, 1904 (1960).
Kappe, T., and Armstrong, M. D., J. Med. Chem., 8, 368 (1965).
Sinistri, C., and Villa, L., Farmaco, Ed. Sci., 17, 949 (1962).
Lewis, G. P., Brit. J. Pharmacol., 9, 488 (1954).
Pratesi, P., and Grana, E., in Advances in Drug Research (edit. by Harper, N. J., and Simmonds, A. B.), II, 127 (Academic Press, London and New York, 1965).
Chapman, N. B., and Triggle, D. J., J. Chem. Soc., 1385 (1963).
Belleau, B., and Triggle, D. J., J. Med. Chem., 5, 636 (1962).
Hyne, J. D., Canad. J. Chem., 39, 2563 (1961).
Kier, L. B., J. Pharm. Pharmacol., 21, 93 (1969).
Hammett, L. P., Physical Organic Chemistry, 193 (McGraw-Hill, New York and London, 1940).
Jarré, H. H., Chem. Rev., 53, 191 (1953).
Engelhardt, A., Hoefke, W., and Wick, H., Arnziemittel-Forschung, 11, 521 (1961).
Trendelenburg, U., Muskus, A., Fleming, W. W., and de la Sierra, B. G. A., J. Pharmacol. Exp. Ther., 138, 170 (1962).
Maxwell, R. A., Povalski, H., and Plummer, A. J., J. Pharmacol. Exp. Ther., 125, 178 (1959).
Senoh, S., and Witkop, B., J. Amer. Chem. Soc., 81, 6222 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LARSEN, A. Catecholamine Chemical Species at the Adrenergic Receptors. Nature 224, 25–27 (1969). https://doi.org/10.1038/224025a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/224025a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.