Abstract
STUDIES of the three chief classes of immunoglobulins in the rabbit, IgG, IgA and IgM, have shown that they all possess the basic four chain structure proposed by Porter1 of two light and two heavy chains, and that while the light chains are common to all three classes the heavy chains, γ, α and μ respectively, are class specific, and differ considerably as judged by pep tide mapping2,3. Despite these differences in the heavy chains the allotypic specificities at the a locus, Aa1, Aa2 and Aa3 (ref. 4), are present not only on the γ chain but also on the α and μ-chains5–7. These specificities have been shown to be on the Fd fragment of γ-chain8 and appear to correlate with the N-terminal sequence of that chain9. In the light of these findings it seemed reasonable to expect that similar structures would be present in the N-terminal sequence of both a and μ-chains, and I have attempted to show this by determining the N-terminal sequence of α-chain from rabbits homozygous for the allotypes Aa1 and Aa3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Porter, R. R., in Basic Problems of Neoplastic Disease (edit. by Gellhorn, A., and Hirshberg, E.), 177 (Columbia Univ. Press, New York, 1962).
Lamm, M. E., and Small, P. A., Biochemistry, 5, 267 (1966).
Cebra, J. J., and Small, P. A., Biochemistry, 6, 503 (1967).
Dray, S., Dubiski, S., Kelus, A. S., Lennox, E. S., and Oudin, J., Nature, 195, 785 (1962).
Todd, C. W., Biochem. Biophys. Res. Commun., 11, 170 (1963).
Feinstein, A., Nature, 199, 1197 (1963).
Pernis, B., Torrigiani, G., Amante, L., Kelus, A. S., and Cebra, J. J., Immunology, 14, 445 (1968).
Feinstein, A., Gell, P. G. H., and Kelus, A. S., Nature, 200, 653 (1963).
Wilkinson, J. M., Biochem. J., 112, 173 (1969).
Cebra, J. J., and Robbins, J. B., J. Immunol., 97, 12 (1966).
Crumpton, M. J., and Wilkinson, J. M., Biochem. J., 88, 228 (1963).
Koshland, M. E., Reisfeld, R. A., and Dray, S., Immunochemistry, 5, 471 (1968).
Inman, J. K., and Reisfeld, R. A., Immunochemistry, 5, 415 (1968).
Koshland, M. E., Cold Spring Harb. Symp. Quant. Biol., 32, 119 (1967).
Gray, W. R., in Methods in Enzymology (edit. by Hirs, C. H. W.), 11, 139 (Academic Press, New York, 1967).
Wilkinson, J. M., Press, E. M., and Porter, R. R., Biochem. J., 100, 303 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WILKINSON, J. α-Chains of Immunoglobulin A from Rabbits of Different Allotype: Composition and N-Terminal Sequence. Nature 223, 616–617 (1969). https://doi.org/10.1038/223616a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/223616a0
This article is cited by
-
Immunogenetic study on the polymorphism of serum ?2-lipoproteins in mink. II. Identification of allotypes Lpm-7 and Lpm-8 and genetic control of seven markers of the Lpm system
Biochemical Genetics (1978)
-
The molecular, mechanistic and immunological properties of amine oxidases
Molecular and Cellular Biochemistry (1976)
-
N-terminal sequences of secretory piece and of α chains of different allotype in rabbit secretory IgA
Nature (1975)
-
Restricted Structural Heterogeneity in Antibodies: Might Different Heavy Chains have a Common Light Chain?
Nature New Biology (1972)
-
Variability of Interchain Binding of Immunoglobulins: Interchain Bridges of Mouse IgG2a and IgG2b
Nature (1970)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.