Abstract
THE work reported here grew out of our studies of the possible role of inorganic pyrophosphate in calcium homeostasis1,2, as a result of which we proposed that the inorganic pyrophosphate known to be present in bone3–5 may be a factor that regulates the rates of formation arid resorption of bone mineral. This hypothesis was based on the observation that pyrophosphate retarded both the growth1,6 and dissolution1,7 of apatite crystals in vitro. According totthe hypothesis, the amount of pyrophosphate present at sies of formation and of resorption in bone would be controlled separately by different pyrophosphatases, the activity of which would in turn be controlled by hormones and other agents. Disturbances in this control might be responsible for various diseases of bone.
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FLEISCH, H., RUSSELL, R., SIMPSON, B. et al. Prevention by a Diphosphonate of Immobilization “Osteoporosis” in Rats. Nature 223, 211–212 (1969). https://doi.org/10.1038/223211a0
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DOI: https://doi.org/10.1038/223211a0
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