Abstract
THE recent report by Bremer, Nützenadel and Bickel1 of the use of prepared thin-layer plates of cellulose for screening of plasma for inborn errors of amino-acid metabolism prompts us to report our experience with prepared cellulose layers on aluminium foil (E. Merck, Darmstadt, Germany) for screening of both plasma and urine. Thin-layer chromatography of amino-acids on cellulose is faster, and has greater sensitivity and resolution, than paper chromatography2,3 without sample preparation. Additionally, the flexible aluminium foils can be dipped in the location reagent instead of being sprayed, and appropriate sections cut out for testing with specific reagents.
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Bremer, H. J., Nützenadel, W., and Bickel, H., Mschr. Kinderheilk., 117, 32 (1969).
Scriver, C. R., Davies, E., and Cullen, A. M., Lancet, ii, 230 (1964).
Efron, M. L., Young, D., Mozer, H. W., and MacCready, R. A., New Engl. J. Med., 270, 1378 (1964).
Woolf, L. I., Gt Ormond St J., 2, 61 (1951).
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ERSSER, R., SEAKINS, J. Screening for Aminoacidopathies with Prepared Cellulose Layers on Aluminium Foil. Nature 223, 1388 (1969). https://doi.org/10.1038/2231388a0
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DOI: https://doi.org/10.1038/2231388a0
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