Abstract
XENOGRAFTS, that is, grafts of which donor and recipient are members of different species, are, as a general rule, destroyed even more rapidly than allografts of similar tissue. Until recently all procedures that were effective in prolonging the lives of allografts—for example, induction of immunological tolerance in the host, treatment of the host with immunosuppressive agents and so on—were usually ineffective for sustaining xenogeneic grafts. These empirical observations led to the suggestion that non-immunological factors, for example, syngeneic preference, metabolic shortcomings of the host and so on, may underlie the failure of xenografts to thrive1,2.
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SHAFFER, C. Transfer of Immunity against Long Surviving Rat Skin Xenografts by Antilymphocyte Serum treated Syrian Hamsters. Nature 223, 1375–1377 (1969). https://doi.org/10.1038/2231375a0
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DOI: https://doi.org/10.1038/2231375a0
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