Abstract
LASIOCARPINE, a pyrrolizidine alkaloid extracted from Heliotropium lasiocarpium and from Heliotropium europaeum, is well known for its hepatotoxicity1. Histological lesions induced by lasiocarpine are localized in the centrilobular zone of the liver2 as are those produced by other hepatotoxins such as dimethylnitrosamine3, cycasin4 and carbon tetrachloride5. Aflatoxin, a very potent hepatocarcinogen synthesized by Aspergillus flavus, on the other hand, induced morphological alterations in the periportal region of the lobule6.
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References
Bull, L. B., Culvenor, C. C. J., and Dick, A. T., The Pyrrolizidine Alkaloids (North Holland, Amsterdam, 1968).
Schoental, R., and Magee, P. N., J. Path. Bacteriol., 74, 305 (1957).
Barnes, J. M., and Magee, P. N., Brit. J. Indust. Med., 11, 167 (1954).
Laqueur, G. L., Mickelsen, O., Whiting, M. G., and Kurland, L. T., J. Nat. Cancer Inst., 31, 919 (1963).
Cameron, G. R., and Karunaratne, W. A. E., J. Path. Bacteriol., 42, 1 (1936).
Butler, W. H., Brit. J. Cancer, 18, 756 (1964).
Svoboda, D., and Soga, J., Amer. J. Pathol., 48, 347 (1966).
Monneron, A., Lafarge, C., and Frayssinet, C., CR Acad. Sci., série D, 267, 2053 (1968).
Reddy, J., Harris, G., and Svoboda, D., Nature, 217, 659 (1968).
Chauveau, J., Moulé, Y., and Rouiller, C., Exp. Cell Res., 11, 317 (1956).
Busch, S., Chambon, P., Mandel, P., and Weill, J. D., Biochem. Biophys. Res. Commun., 7, 255 (1962).
Moulé, Y., and Frayssinet, C., Nature, 218, 93 (1968).
Loeb, J., Biochim. Biophys. Acta, 145, 427 (1967).
Nakamoto, T., Fox, C. F., and Weiss, S. B., J. Biol. Chem., 239, 167 (1964).
Bernhard, W., Frayssinet, C., Lafarge, C., and Le Breton, E., CR Acad. Sci., 261, 1785 (1965).
Lafarge, C., Frayssinet, C., and de Recondo, A. M., Bull. Soc. Chim. Biol., 47, 1724 (1965).
Clifford, J. I., and Rees, K. R., Nature, 209, 312 (1966).
Sporn, M. B., Dingman, C. W., Longacre Phielps, H., and Woogan, G. N., Science, 151, 1539 (1966).
De Recondo, A. M., Frayssinet, C., Lafarge, C., and Le Breton, E., Biochim. Biophys. Acta, 119, 322 (1966).
Stirpe, F., and Fiume, L., Biochem. J., 105, 779 (1967).
Widnell, C. C., and Tata, J. R., Biochim. Biophys. Acta, 87, 531 (1964).
Chambon, P., Ramuz, M., Mandel, P., and Doly, J., Biochim. Biophys. Acta, 157, 504 (1968).
Chambon, P., Ramuz, M., and Doly, J., Biochem. Biophys. Res. Commun., 21, 156 (1965).
Mattocks, A. R., Nature, 217, 723 (1968).
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FRAYSSINET, C., MOULÉ, Y. Effect of Lasiocarpine on Transcription in Liver Cells. Nature 223, 1269–1270 (1969). https://doi.org/10.1038/2231269a0
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DOI: https://doi.org/10.1038/2231269a0
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