Abstract
WHEN human leucocytes from two normal unrelated individuals are cultured together, some of the small lymphocytes which show a blastoid transformation can synthesize DNA and undergo mitosis1, and it has been suggested that such a reaction in the mixed leucocyte cultures is related to homograft immunity arid genetic differences between two individuals. We have investigated the blastoid response in mixed leucocyte cultures of normal persons (NP) and Down's syndrome (DS) patients using autoradiographic and karyotypic analyses.
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References
Bain, B., Vas, M. R., and Lowenstein, L., Blood, 23, 108 (1964).
Hirschhorn, K., Bach, F., and Kolodny, R. L., Science, 142, 1185 (1963).
Hayakawa, H., Matsui, I., Higurashi, M., and Kobayashi, N., Lancet, i, 95 (1968).
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SASAKI, M., OBARA, Y. Hypersensitivity of Lymphocytes in Down's Syndrome shown by Mixed Leucocyte Culture Experiments. Nature 222, 596–598 (1969). https://doi.org/10.1038/222596b0
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DOI: https://doi.org/10.1038/222596b0
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