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Interaction of Artificial Phospholipid Membranes with Isolated Polymorphonuclear Leucocytic Granules

Abstract

AFTER the engulfment of particles by rabbit polymorphonuclear (PMN) leucocytes, the membrane of granulocytic lysosomes fuses with the membrane of the phagocytic vacuole, thereby allowing lysosomal enzymes access to the ingested material1. To try to understand this specific interaction between lysosomal and vacuolar membranes, we have studied a cell-free system containing isolated PMN granules with artificial model membranes substituted for the vacuolar membrane.

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HAWIGER, J., COLLINS, R., HORN, R. et al. Interaction of Artificial Phospholipid Membranes with Isolated Polymorphonuclear Leucocytic Granules. Nature 222, 276–278 (1969). https://doi.org/10.1038/222276a0

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