Abstract
Factors present in normal rabbit serum induce adirectional migration of neutrophils and macrophages. The movement of neutrophils is enhanced by the addition of antigen–antibody complex to the serum, while the movement of macrophages is depressed. A complex pattern of synergism and inhibition appears when serum fractions are combined.
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References
Pfeffer, W., Untersuchungen aus dem Botanischen Institut TĂĽbingen, 1, 363 (1884).
Keller, H. U., and Sorkin, E., Experientia, 24, 641 (1968).
Adler, J., Science, 153, 708 (1966).
McCutcheon, M., Physiol. Rev., 26, 319 (1946).
Harris, H., Physiol. Rev., 34, 529 (1954); in Function of the Blood (edit. by MacFarlane, R. G., and Smith, A. G. T.), 463 (Academic Press, New York, 1961).
Keller, H. U., and Sorkin, E., Immunology, 9, 441 (1965).
Boyden, S. V., J. Exp. Med., 115, 453 (1962).
Ward, P. A., Cochrane, C. G., and MĂĽller-Eberhard, H. J., J. Exp. Med., 122, 327 (1965).
Cornely, H. P., Proc. Soc. Exp. Biol. NY, 122, 831 (1966).
Keller, H. U., and Sorkin, E., Int. Arch. Allergy, 31, 505 (1967).
Taylor, F. B., and Ward, P. A., J. Exp. Med., 126, 149 (1967).
Ward, P. A., Cochrane, C. G., and MĂĽller-Eberhard, H. J., Immunology, 11, 141 (1966).
Ward, P. A., J. Exp. Med., 126, 189 (1967).
Keller, H. U., and Sorkin, E., Int. Arch. Allergy, 31, 575 (1967).
Keller, H. U., and Sorkin, E., Experientia, 23, 549 (1967).
Determann, H., Gelchromatographie, 118 (Springer, Heidelberg, 1967).
Snyderman, R., Gewurz, H., and Mergenhagen, S. E., J. Exp. Med., 128, 259 (1968).
Shin, S., Snyderman, R., Friedmann, E., Mellors, A., and Mayer, M., Science, 162, 361 (1968).
Ketchel, M. M., and Favour, C. B., J. Exp. Med., 101, 647 (1955).
Borel, J. F., Keller, H. U., and Sorkin, E., Int. Arch. Allergy, 35, 194 (1969).
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WILKINSON, P., BOREL, J., STECHER-LEVIN, V. et al. Macrophage and Neutrophil Specific Chemotactic Factors in Serum. Nature 222, 244–247 (1969). https://doi.org/10.1038/222244a0
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DOI: https://doi.org/10.1038/222244a0
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