Abstract
GALACTOSE is a physiological substance which is usually well tolerated provided its breakdown is normal. In patients with galactosaemia, who lack the enzyme galactose-1-phosphate uridyl transferase, galactose is toxic, causing cataract and brain and liver damage, presumably because of the accumulation of galactose-1-phosphate1. The exact mechanism involved is not known, however, and extensive studies have been hampered by the lack of an experimental model.
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TYGSTRUP, N., KEIDING, S. Lethal Effect of Feeding Rats on Galactose–Ethanol. Nature 222, 181 (1969). https://doi.org/10.1038/222181a0
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DOI: https://doi.org/10.1038/222181a0
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