Abstract
FOR some time it has been thought that the generation of antibody-forming cells (AFC) may involve an interaction between cell types1–3. We present here a stochastic model, based on a two-cell interaction system, for the production of AFC. The assumptions on which the model is based have chiefly come from an interpretation of two types of experimental data, each of which can yield information concerning the number of cells involved. The first is limiting dilution analysis, which is based on the Poisson probability distribution. The second is dose–response analysis, showing the relationship between lymphoid cell dose and the number of AFC generated. These types of experiments involve either the transfer of lymphoid cells to irradiated, compatible recipients or the growth of lymphoid cells in diffusion chamber cultures.
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References
Fishman, M., Nature, 183, 1200 (1959).
Mosier, D. E., Science, 158, 1573 (1967).
Davies, A. J. S., Leuchars, E., Wallis, V., Marchant, R., and Elliott, E. V., Transplantation, 5, 222 (1967).
Brown, R. A., Makinodan, T., and Albright, J. F., Nature, 210, 1383 (1966).
Kennedy, J. C., Till, J. E., Siminovitch, L., and McCulloch, E. A., J. Immunol., 96, 973 (1966).
Bosma, M. J., Makinodan, T., and Walburg, jun., H. E., J. Immunol., 99, 420 (1967).
Groves, D. L., Fed. Proc., 27, 318 (1968).
Perkins, E. H., Robinson, M. A., and Makinodan, T., J. Immunol., 86, 533 (1961).
Makela, O., and Mitchison, N. A., Immunology, 8, 539 (1965).
Santos, G. W., and Owens, jun., A. H., Bull. Johns Hopkins Hosp., 118, 109 (1966).
Albright, J. F., and Makinodan, T., in Molecular and Cellular Basis of Antibody Formation (edit. by Sterzl, J., et al.), 427 (Academic Press, New York, 1965).
Bosma, M. J., Perkins, E. H., and Makinodan, T., J. Immunol., 101, 963 (1968).
Celada, F., J. Exp. Med., 125, 199 (1967).
Bussard, A. E., and Lurie, M., J. Exp. Med., 125, 873 (1967).
Gregory, C. J., and Lajtha, L. G., Nature, 218, 1079 (1968).
Luzzati, A. L., Tosi, R. M., Carbonara, A. O., and Ceppellini, R., Atti Ass. Genet. Ital., 13, 239 (1968).
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GROVES, D., LEVER, W. & MAKINODAN, T. Stochastic Model for the Production of Antibody-forming Cells. Nature 222, 95–97 (1969). https://doi.org/10.1038/222095a0
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DOI: https://doi.org/10.1038/222095a0
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