Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Antiviral Effect of Daunomycin

Nature volume 222, pages 36–38 (1969)Cite this article

Abstract

Daunomycin, an antibiotic of the anthracycline group, acts chiefly on DNA and DNA-dependent RNA synthesis. Although too toxic for routine systemic administration, local application of daunomycin for the treatment of herpetic or vaccinial keratitis might be possible, particularly if the infecting virus has become resistant to 5-iodo-2-deoxyuridine.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Grein, A., Spalla, C., Di Marco, A., and Canevazzi, G., Giorn. Microbiol., 11, 109 (1963).

    Google Scholar 

  2. Sanfilippo, A., and Mazzoleni, R., Giorn. Microbiol., 12, 83 (1964).

    Google Scholar 

  3. Tan, C., Tasaka, H., Yu, K-P., Murphy, M. L., and Karnofsky, D. A., Cancer, 20, 333 (1967).

    Article  CAS  Google Scholar 

  4. Rusconi, A., and Calendi, E., Biochim. Biophys. Acta, 119, 413 (1966).

    Article  CAS  Google Scholar 

  5. Di Marco, A., Silvestrini, R., Di Marco, S., and Dasdia, T., J. Cell Biol., 27, 545 (1965).

    Article  CAS  Google Scholar 

  6. Silvestrini, R., Di Marco, A., Di Marco, S., and Dasdia, T., Tumori, 49, 399 (1963).

    Article  CAS  Google Scholar 

  7. Calendi, E., Di Marco, A., Reggiani, M., Scarpinato, B., and Valentini, L., Biochim. Biophys. Acta, 103, 25 (1965).

    Article  CAS  Google Scholar 

  8. Hartmann, G., Goller, H., Koschell, K., Kersten, W., and Kersten, H., Biochem. Z., 341, 126 (1964).

    PubMed  CAS  Google Scholar 

  9. Ward, D. C., Reich, E., and Goldberg, I. H., Science, 149, 1259 (1965).

    Article  ADS  CAS  Google Scholar 

  10. Di Marco, A., Gaetani, M., Orezzi, P., Scarpinato, B. M., Silvestrini, R., Soldati, M., Dasdia, T., and Valentini, L., Nature, 201, 706 (1964).

    Article  ADS  CAS  Google Scholar 

  11. Kersten, W., and Kersten, H., Biochem. Z., 341, 174 (1965).

    PubMed  CAS  Google Scholar 

  12. Di Marco, A., Pathologie et Biologie, 15, 897 (1967).

    PubMed  CAS  Google Scholar 

  13. Costa, G., and Astaldi, G., Tumori, 50, 477 (1964).

    Article  CAS  Google Scholar 

  14. Di Marco, A., Soldati, M., Fioretti, A., and Dasdia, T., Tumori, 49, 235 (1963).

    Article  CAS  Google Scholar 

  15. Di Marco, A., Soldati, M., Fioretti, A., and Dasdia, T., Cancer Chemother. Rep., 38, 39 (1964).

    CAS  Google Scholar 

  16. Magliulo, E., Stassano, G., and Fiori, G. P., Haematologica, 49, 1091 (1964).

    CAS  Google Scholar 

  17. Dorigotti, L., Tumori, 50, 117 (1964).

    Article  CAS  Google Scholar 

  18. Simard, R., Cancer Res., 26, 2316 (1966).

    PubMed  CAS  Google Scholar 

  19. Finter, N. B., Virology, 24, 589 (1964).

    Article  CAS  Google Scholar 

  20. Ginzburg, Y., and Traub, A., Virology, 9, 671 (1959).

    Article  CAS  Google Scholar 

  21. Barry, I. D., Ives, D. R., and Cruickshank, J. G., Nature, 194, 1139 (1962).

    Article  ADS  CAS  Google Scholar 

  22. Reich, E., Franklin, R. M., Shatkin, A. J., and Tatum, E. L., Proc. Nat. Acad. Sci. Wash., 48, 1238 (1962).

    Article  ADS  CAS  Google Scholar 

  23. Reich, E., and Goldberg, I. H., in Progress in Nucleic Acid Research and Molecular Biology (edit. by Davidson, J. N., and Cohn, W. E.), 3, 184 (Academic Press, New York, 1964).

    Google Scholar 

  24. Rees, K. R., in The Interaction of Drugs and Subcellular Components on Animal Cells (edit. by Campbell, P. N.) (Churchill Ltd, London, 1968).

    Google Scholar 

  25. Read, L. J., and Muench, H., Amer. J. Hyg., 27, 493 (1938).

    Google Scholar 

  26. Bauer, D. J., and Apostolov, K., Science, 154, 796 (1966).

    Article  ADS  CAS  Google Scholar 

  27. Sabin, A. B., in Cellular Biology, Nucleic Acids and Viruses, 5, 113 (New York Academy of Sciences, 1957).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Bacteriology,

    A. COHEN

  2. Department of Chemical Pathology, University College Hospital Medical School, London

    E. H. HARLEY & K. R. REES

Authors
  1. A. COHEN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. H. HARLEY
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. R. REES
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

COHEN, A., HARLEY, E. & REES, K. Antiviral Effect of Daunomycin. Nature 222, 36–38 (1969). https://doi.org/10.1038/222036a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/222036a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing