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Effect of Extra-corporeal Irradiation of the Blood on Bone Marrow Activity in Acute Leukaemia

Nature volume 221, pages 972–974 (1969)Cite this article

Abstract

THE development of satisfactory techniques for establishing arteriovenous shunts, as used for haemodialysis, has made extra-corporeal irradiation of the blood (ECI) a technically feasible and safe procedure. Its use in the treatment of acute leukaemia1–3 has been based on the theoretical assumption that exchange of leukaemic cells between blood and bone marrow may take place, and that continued irradiation of the blood might eventually lead to the destruction of a large proportion of the total burden of leukaemic cells.

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Authors and Affiliations

  1. Department of Medicine, University of Cambridge,

    B. W. B. CHAN & F. G. J. HAYHOE

  2. Department of Radiotherapeutics, Addenbrooke's Hospital, Cambridge

    J. A. BULLIMORE

Authors
  1. B. W. B. CHAN
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  2. F. G. J. HAYHOE
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  3. J. A. BULLIMORE
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CHAN, B., HAYHOE, F. & BULLIMORE, J. Effect of Extra-corporeal Irradiation of the Blood on Bone Marrow Activity in Acute Leukaemia. Nature 221, 972–974 (1969). https://doi.org/10.1038/221972a0

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