Abstract
ERGOCORNINE and ergocristine prevent pregnancy in rats when injected once during the first 7 days after copulation1. In a broad study of the pharmacological properties of ergolene and ergoline derivatives, we found that a similar effect is exerted by D-6-methyl-8-cyanomethylergoline(I), also known as “6605-VUFB”, which has been synthesized2 in our institute.
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References
Shelesnyak, M. C., Recent Progress in Hormone Research, 13, 269 (1957).
Semonský, M., and Kucharczyk, N., Collection Czechoslov. Chem. Commun., 33, 577 (1968).
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ŘEŽÁBEK, K., SEMONSKÝ, M. & KUCHARCZYK, N. Suppression of Conception with D-6-Methyl-8-cyanomethylergoline(I) in Rats. Nature 221, 666–667 (1969). https://doi.org/10.1038/221666a0
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DOI: https://doi.org/10.1038/221666a0
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