Abstract
THE microsomal hydroxylation of para-halogen substituted anilines, acetanilides and aromatic amino-acids, with subsequent migration of the halogen function, has been termed the NIH shift1–4.
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Guroff, G., Kondo, K., and Daly, J., Biochem. Biophys. Res. Commun., 25, 622 (1966).
Jerina, D., Daly, J., Landis, W., and Witkop, B., J. Amer. Chem. Soc., 89, 3347 (1967).
Guroff, G., Daly, J. W., Jerina, D. M., Renson, J., Witkop, B., and Udenfriend, S., Science, 157, 1524 (1967).
Daly, J. W., Guroff, G., Udenfriend, S., and Witkop, B., Biochem. Pharmacol., 17, 31 (1968).
Newbould, B. B., Ann. Rheum. Dis. (in the press).
Emmons, W. D., J. Amer. Chem. Soc., 76, 3468 (1954).
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FOULKES, D. Metabolism of Thiazole Acetic Acid Derivatives and the NIH Shift. Nature 221, 582 (1969). https://doi.org/10.1038/221582a0
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DOI: https://doi.org/10.1038/221582a0
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