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Sedimentation Velocity Properties of Complex Mitochondrial DNA

Nature volume 221, pages 332–337 (1969)Cite this article

Abstract

The interlocked duplex DNA rings in a catenane appear to sediment as independent units when the rings are relaxed and as connected units when the rings are in a superhelical conformation.

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References

  1. Hudson, B., and Vinograd, J., Nature, 216, 647 (1967).

    Article  ADS  CAS  Google Scholar 

  2. Clayton, D. A., and Vinograd, J., Nature, 216, 652 (1967).

    Article  ADS  CAS  Google Scholar 

  3. Radloff, R., Bauer, W., and Vinograd, J., Proc. US Nat. Acad. Sci., 57, 1514 (1967).

    Article  ADS  CAS  Google Scholar 

  4. Borst, P., and Kroon, A. N., Intern. Rev. Cytol. (in the press).

  5. Vinograd, J., Lebowitz, J., Radloff, R., Watson, R., and Laipis, P., Proc. US Nat. Acad. Sci., 53, 1104 (1965).

    Article  ADS  CAS  Google Scholar 

  6. Crawford, L. V., J. Mol. Biol., 13, 362 (1965).

    Article  CAS  Google Scholar 

  7. Ruttenberg, G. J. C. M., Smit, E. M., Borst, P., and van Bruggen, E. F. J., Biochim. Biophys. Acta, 157, 429 (1968).

    Article  CAS  Google Scholar 

  8. Bruner, R., and Vinograd, J., Biochim. Biophys. Acta, 108, 18 (1965).

    Article  CAS  Google Scholar 

  9. Dawid, I. B., and Wolstenholme, D. R., J. Mol. Biol., 28, 233 (1967).

    Article  CAS  Google Scholar 

  10. Crothers, D. M., and Zimm, B. H., J. Mol. Biol., 12, 525 (1965).

    Article  CAS  Google Scholar 

  11. Gray, jun., H. B., Bloomfield, V. A., and Hearst, J. E., J. Chem. Phys., 46, 1493 (1967).

    Article  ADS  CAS  Google Scholar 

  12. Burton, A., and Sinsheimer, R. L., J. Mol. Biol., 14, 327 (1965).

    Article  CAS  Google Scholar 

  13. Wang, J. C., and Davidson, N., J. Mol. Biol., 15, 111 (1966).

    Article  CAS  Google Scholar 

  14. Rhoades, M., and Thomas, jun., C. A., J. Mol. Biol. (in the press).

  15. Hershey, A. D., Burgi, E., and Ingraham, L., Proc. US Nat. Acad. Sci., 49, 748 (1963).

    Article  ADS  CAS  Google Scholar 

  16. Bazaral, M., and Helinski, D., Biochemistry (in the press).

  17. Ray, D. S., Preuss, A., and Hofschneider, P. H., J. Mol. Biol., 21, 485 (1966).

    Article  CAS  Google Scholar 

  18. Crawford, L. V., J. Mol. Biol., 13, 362 (1965).

    Article  CAS  Google Scholar 

  19. Rush, M. G., Kleinschmidt, A. K., Hellmann, W., and Warner, R. C., Proc. US Nat. Acad. Sci., 58, 1676 (1967).

    Article  ADS  CAS  Google Scholar 

  20. Kiger, J. A., Young, E. T., and Sinsheimer, R. L., J. Mol. Biol., 33, 395 (1968).

    Article  CAS  Google Scholar 

  21. Young, E. T., and Sinsheimer, R. L., J. Mol. Biol., 30, 165 (1967).

    Article  CAS  Google Scholar 

  22. Bauer, W., and Vinograd, J., J. Mol. Biol., 33, 141 (1968).

    Article  CAS  Google Scholar 

  23. Bloomfield, V. A., Proc. US Nat. Acad. Sci., 55, 717 (1966).

    Article  ADS  CAS  Google Scholar 

  24. Fukatsu, M., and Kurata, M., J. Chem. Phys., 44, 4539 (1966).

    Article  ADS  CAS  Google Scholar 

  25. Tanford, C., in Physical Chemistry of Macromolecules, 327 (Wiley, New York, 1961).

    Google Scholar 

  26. Kirkwood, J. G., and Riseman, J., J. Chem. Phys., 16, 565 (1948).

    Article  ADS  CAS  Google Scholar 

  27. Burgers, J. M., Proc. Acad. Sci. Amsterdam, 45, 9 (1942).

    CAS  Google Scholar 

  28. Schachman, H. K., Ultracentrifugation in Biochemistry (Academic Press, New York, 1959).

    Google Scholar 

  29. Wang, J. C., and Schwartz, H., Biopolymers, 5, 953 (1967).

    Article  CAS  Google Scholar 

  30. Schatz, G., Haselbrunner, E., and Tuppy, J., Biochem. Biophys. Res. Commun., 15, 127 (1964).

    Article  CAS  Google Scholar 

  31. Shapiro, L., Grossman, L. I., and Marmur, J., J. Mol. Biol., 33, 907 (1968).

    Article  CAS  Google Scholar 

  32. Vinograd, J., Bruner, R., Kent, R., and Weigle, J., Proc. US Nat. Acad. Sci., 49, 902 (1963).

    Article  ADS  CAS  Google Scholar 

Download references

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Author notes

  1. BRUCE HUDSON

    Present address: Department of Chemistry, Harvard University, Cambridge, Massachusetts

Authors and Affiliations

  1. Divisions of Chemistry and Biology, California Institute of Technology, Pasadena, California

    BRUCE HUDSON & JEROME VINOGRAD

Authors
  1. BRUCE HUDSON
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  2. JEROME VINOGRAD
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HUDSON, B., VINOGRAD, J. Sedimentation Velocity Properties of Complex Mitochondrial DNA. Nature 221, 332–337 (1969). https://doi.org/10.1038/221332a0

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