Abstract
A PREVIOUS study has shown that the administration of antilymphocyte serum (ALS) resulted in augmentation of “takes”, growth and metastases of transplanted mouse mammary tumours in their syngeneic C3HeB/FeJ hosts1. The mechanism concerned with this effect was not indisputably evident, although it seemed likely that it was related to the lymphopenic and/or other immuno-suppressive activity of ALS. Although tumour specific transplantation antigens (TSTA) have been demonstrated recently in “spontaneous” mammary tumours of C3H mice, there is some evidence that TSTA in such neoplasms are “weak”2. Because of this, we thought it worth while to explore the effects of ALS on parameters of tumour growth of MCA-induced tumours in which TSTA and immunological mechanisms are more firmly established.
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References
Fisher, B., Soliman, O., and Fisher, E. R., Proc. Soc. Exp. Biol. and Med. (in the press).
Silobrcic, V., and Suit, H. D., J. Nat. Cancer Inst., 39, 1113 (1967).
Gray, J. G., Monaco, A. P., Wood, M. L., and Russell, P. S., J. Immunol., 96, 217 (1966).
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FISHER, E., SOLIMAN, O. & FISHER, B. Effect of Antilymphocyte Serum on Parameters of Growth of MCA-induced Tumours. Nature 221, 287–288 (1969). https://doi.org/10.1038/221287a0
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DOI: https://doi.org/10.1038/221287a0
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