Abstract
THE procedure used to purify genetically a virus preparation does not guarantee the homogeneity of the derived population1. Genetic purity can be defined by markers characteristic of a given virus. During studies of the selective effects of cloned and uncloned lines of human epithelial cells on a relatively non-cytopathic strain of type 2 poliovirus, MEF12,3, efforts to obtain genetically pure virus stocks failed. We describe here a study undertaken to explain this failure.
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MCCORMICK, K., MURPHY, W. Genetic Heterogeneity of Cloned Animal Virus Preparations. Nature 221, 286 (1969). https://doi.org/10.1038/221286a0
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DOI: https://doi.org/10.1038/221286a0
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