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Role of the Vagus Nerve in the Control of the Concentration of Angiotensin II in the Circulation

Nature volume 221, pages 177–179 (1969)Cite this article

Abstract

HAEMORRHAGE causes an increase of the concentration of renin1–4 and of angiotensin5–8 in blood; when the blood volume of anaesthetized dogs is reduced this rise in concentration of renin4 and of angiotensin7 can be prevented by local anaesthesia of the renal nerves, which suggests that it is brought about by reflex activation of the nerves. The changes of angiotensin concentration correlate not with changes of arterial pressure but with changes of central venous pressure7. Changes of central venous pressure are usually accompanied by changes of pressure in the atria and the pulmonary circulation; these areas are plentifully supplied by vagal afferent fibres and so it seemed possible that the vagus nerve might form the afferent limb of the reflex. We have therefore studied the effect on the generation of angiotensin of interrupting conduction in the vagus nerve.

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References

  1. Hamilton, A. S., and Collins, D. A., Amer. J. Physiol., 136, 275 (1942).

    Google Scholar 

  2. Dexter, L., Frank, H. A., Haynes, F. W., and Altschule, M. D., J. Clin. Invest., 22, 847 (1943).

    Article  CAS  Google Scholar 

  3. Brown, J. J., Davies, D. L., Lever, A. F., Robertson, J. I. S., and Verniory, A., J. Physiol., 182, 649 (1966).

    Article  CAS  Google Scholar 

  4. Bunag, R. D., Page, I. H., and McCubbin, J. W., Circulation Res., 19, 851 (1966).

    Article  CAS  Google Scholar 

  5. Scornik, O. A., and Paladini, A. C., Amer. J. Physiol., 206, 553 (1964).

    CAS  Google Scholar 

  6. Regoli, D., and Vane, J. R., J. Physiol., 183, 513 (1966).

    Article  CAS  Google Scholar 

  7. Hodge, R. L., Lowe, R. D., and Vane, J. R., J. Physiol., 185, 613 (1966).

    Article  CAS  Google Scholar 

  8. Brown, J. J., Hodge, R. L., Lever, A. F., Lowe, R. D., Robertson, J. I. S., and Vane, J. R., Nature, 215, 853 (1967).

    Article  ADS  CAS  Google Scholar 

  9. Vane, J. R., Brit. J. Pharmacol. Chemother., 23, 360 (1964).

    Article  CAS  Google Scholar 

  10. Vane, J. R., Brit. J. Pharmacol. Chemother., 12, 344 (1957).

    Article  CAS  Google Scholar 

  11. Regoli, D., and Vane, J. R., Brit. J. Pharmacol. Chemother., 23, 351 (1964).

    Article  CAS  Google Scholar 

  12. Gaddum, J. H., Brit. J. Pharmacol. Chemother., 8, 321 (1953).

    Article  CAS  Google Scholar 

  13. Paton, W. D. M., J. Physiol., 137, 35P (1953).

    Google Scholar 

  14. Armitage, A. K., and Vane, J. R., Brit. J. Pharmacol. Chemother., 22. 204 (1964).

    Article  CAS  Google Scholar 

  15. Ng, K. K. F., and Vane, J. R., Nature, 216, 762 (1967).

    Article  ADS  CAS  Google Scholar 

  16. Ng, K. K. F., and Vane, J. R., Nature, 218, 144 (1968).

    Article  ADS  CAS  Google Scholar 

  17. Paintal, A. S., and Rosenberg, M. E., J. Physiol., 189, 6P (1966).

    Google Scholar 

  18. Ferreira, S. H., and Vane, J. R., Nature, 215, 1237 (1967).

    Article  ADS  CAS  Google Scholar 

  19. Gupta, P. D., Henry, J. P., Sinclair, R., and Von Baumgarten, R., Amer. J. Physiol., 211, 1429 (1966).

    CAS  PubMed  Google Scholar 

  20. Gauer, O. H., and Henry, J. P., Physiol. Rev., 43, 423 (1963).

    Article  CAS  Google Scholar 

  21. Baisset, A., and Montastruc, P., J. Physiol. (Paris), 49, 33 (1957).

    CAS  Google Scholar 

  22. Share, L., and Levy, M. N., Amer. J. Physiol., 210, 157 (1966).

    CAS  Google Scholar 

  23. Share, L., and Levy, M. N., Amer. J. Physiol., 203, 425 (1962).

    CAS  PubMed  Google Scholar 

  24. Bartter, F. C., and Gann, D. S., Circulation, 21, 1016 (1960).

    Article  CAS  Google Scholar 

  25. Cort, J. H., and Liechardus, B., Physiol. Bohemoslov., 12, 300 (1963).

    CAS  PubMed  Google Scholar 

  26. Atkins, E. L., and Pearce, J. W., Canad. J. Biochem. Physiol., 37, 91 (1959).

    Article  CAS  Google Scholar 

  27. Gilmore, J. P., and Weisfeldt, M. L., Circulation Res., 17, 144 (1965).

    Article  CAS  Google Scholar 

  28. Hodge, R. L., Lowe, R. D., and Vane, J. R., Nature, 211, 491 (1966).

    Article  ADS  CAS  Google Scholar 

  29. Share, L., Amer. J. Med., 42, 701 (1967).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. R. L. HODGE

    Present address: Department of Physiology, University of Adelaide, Australia

  2. R. D. LOWE

    Present address: Department of Medicine, St Thomas's Hospital Medical School, London, SE1

  3. K. K. F. NG

    Present address: Department of Pharmacology, University of Singapore, Faculty of Medicine, Singapore, 3

Authors and Affiliations

  1. Department of Pharmacology, Institute of Basic Medical Sciences, Royal College of Surgeons of England, Lincoln's Inn Fields, London, WC2

    R. L. HODGE, R. D. LOWE, K. K. F. NG & J. R. VANE

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  1. R. L. HODGE
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  3. K. K. F. NG
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  4. J. R. VANE
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HODGE, R., LOWE, R., NG, K. et al. Role of the Vagus Nerve in the Control of the Concentration of Angiotensin II in the Circulation. Nature 221, 177–179 (1969). https://doi.org/10.1038/221177a0

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