Abstract
THE specific (γ) polypeptide chain of immunoglobulin G (IgG, ref. 1) molecules carries several genetic markers (Gm antigens)2,3 which can be detected by serological techniques. Each of the markers is associated with one of three subclasses of γ chain, called γ1, γ2 or γ3 chains4. (γ1, γ2, γ3 and γ4 are approved designations for the heavy chains of the immunoglobulins IgG 1, IgG 2, IgG 3 an IgG 4, respectively5.) Most Gm antigens have been localized in the Fc region of the IgG molecule; the exceptions are the Gm(z) and (f) markers which are located in the Fd region. At present no genetic marker is known for γ4 chains.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bull. WHO, 30, 447 (1964).
Mårtensson, L., Vox Sang., 11, 521 (1966).
Mårtensson, L., Proc. Eleventh Cong. Intern. Soc. Blood Transf., Sydney 1966, Bibl. Haemat., No. 29, Part 2, 510 (Karger, Basel and New York, 1968).
Natvig, J. B., and Kunkel, H. G., Ser. Haematol., 1, 1, 66 (1968).
Bull. WHO, 35, 953 (1966).
Turner, M. W., and Bennich, H., Biochem. J., 107, 171 (1968).
Mårtensson, L., J. Exp. Med., 120, 1169 (1964).
Natvig, J. B., Kunkel, H. G., Yount, W. J., and Nielsen, J. C., J. Exp. Med., 128, 763 (1968).
Natvig, J. B., Kunkel, H. G., and Joslin, I., J. Immunol. (in the press).
Heimer, R., and Schnoll, S. H., J. Immunol., 100, 231 (1968).
Poulik, M. D., Nature, 210, 133 (1966).
Irimajiri, S., Frangione, B., and Franklin, E. C., Arthritis and Rheumatism, 9, 860 (1966).
Irimajiri, S., Franklin, E. C., and Frangione, B., Immunochemistry, 5, 383 (1968).
Meltzer, M., Franklin, E. C., Fudenberg, H., and Frangione, B., Proc. US Nat. Acad. Sci., 51, 1007 (1964).
Thorpe, M. O., and Deutsch, H. F., Immunochemistry, 3, 329 (1966).
Grey, H. M., and Kunkel, H. G., Biochemistry, 6, 2326 (1967).
Grey, H. M., and Abel, C. A., Immunochemistry, 4, 315 (1967).
Frangione, B., Milstein, C., and Franklin, E. C., Biochem. J., 106, 15 (1968).
Singer, S. J., and Doolittle, R. F., Science, 153, 13 (1966).
Lennox, E. S., and Cohn, M., Ann. Rev. Biochem., 36 (i), 365 (1967).
Hill, R. L., Lebovitz, H. E., Fellows, jun., R. E., and Delaney, R., Third Nobel Symp. Gamma Globulins, Structure and Control of Biosynthesis, 109 (Almqvist and Wiksell, Stockholm.)
Prahl, J. W., Biochem. J., 105, 1019 (1967).
Litwin, S. D., and Kunkel, H. G., Nature, 210, 866 (1966).
Polmar, S. H., and Steinberg, A. G., Science, 145, 928 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TURNER, M., MÅRTENSSON, L., NATVIG, J. et al. Genetic (Gm) Antigens associated with Subfragments from the Fc Fragment of Human Immunoglobulin G. Nature 221, 1166–1169 (1969). https://doi.org/10.1038/2211166a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/2211166a0
This article is cited by
-
A key amino acid determining G3m(b) allotypic markers
Japanese journal of human genetics (1991)
-
The γ1 heavy-chain disease FOR protein is present in two molecular forms
Folia Microbiologica (1984)
-
Rheumatoid Anti Gm Factors with Specificity for the pFc′ Subfragment of Human Immunoglobulin G
Nature (1970)
-
Crystalline Fc prepared in High Yield from Normal Human IgG
Nature (1970)
-
Simple Method of Subtyping Human G-Myeloma Proteins based on Sensitivity to Pepsin Digestion
Nature (1970)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
