Abstract
THE role of nuclear proteins in the regulation of gene activity has received much attention. Although histones have been thought to be repressors of gene activity in eukaryotes1,2, recent evidence indicates that there may be other factors which are of equal or greater importance3,4. These factors may be acid proteins5,6. Certain fractions of non-histone proteins have been found which seem to prevent the transcription of DNA from being completely restricted by histone. This supports the suggestion that the acidic nuclear proteins (the non-histones) are responsible for regulation of gene activity7,8.
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BURDICK, C., HIMES, M. Nuclear Proteins of Hepatocyte and Erythrocyte Nuclei of Frog Liver. Nature 221, 1150–1152 (1969). https://doi.org/10.1038/2211150a0
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DOI: https://doi.org/10.1038/2211150a0
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