Abstract
TREATMENT of pubertal female rats with androgen or oestrogen produces sterility and reduces sexual receptivity in a high percentage of the animals. These hormones seem to alter the normal function of the preoptic—anterior hypothalamic region1–3, which—apparently undifferentiated at birth—is involved in: (1) producing the cyclic ovulatory surge of gonadotropin resulting in ovulation2, and (2) regulating mating behaviour in the female rat4. When allowed to differentiate normally, it regulates the cyclic release of gonadotropin, which is necessary for the normal pattern of sexual behaviour in the female rat. Early treatment with oestrogen or androgen causes the preoptic area to become refractory to both intrinsic and extrinsic activation by stimuli which would usually result in ovulation5.
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McGUIRE, J., LISK, R. Oestrogen Receptors in Androgen or Oestrogen Sterilized Female Rats. Nature 221, 1068–1069 (1969). https://doi.org/10.1038/2211068a0
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DOI: https://doi.org/10.1038/2211068a0
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