Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Mechanism of Action of Reagents that uncouple Oxidative Phosphorylation

Abstract

Uncoupling agents may act by causing conformational transitions in mitochondrial catalytic proteins.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Slater, E. C., in Metabolic Inhibitors, 2 (edit. by Hochster, R. M., and Quastel, J. H.), 503 (Academic Press, New York and London, 1963).

    Book  Google Scholar 

  2. Parker, V. H., Biochem. J., 69, 306 (1958).

    Article  CAS  Google Scholar 

  3. Blackman, G. E., Parke, M. H., and Garton, G., Arch. Biochem. Biophys., 54, 55 (1955).

    Article  CAS  Google Scholar 

  4. Gladtke, E., and Liss, E., Biochim. Z., 331, 65 (1958).

    CAS  Google Scholar 

  5. Hemker, H. C., Biochim. Biophys. Acta, 63, 46 (1962).

    Article  CAS  Google Scholar 

  6. De Deken, R. H., Biochim. Biophys. Acta, 17, 494 (1955).

    Article  CAS  Google Scholar 

  7. Weinbach, E. C., and Garbus, J., Science, 145, 824 (1964).

    Article  ADS  CAS  Google Scholar 

  8. Weinbach, E. C., and Garbus, J., J. Biol. Chem., 240, 1811 (1965).

    PubMed  CAS  Google Scholar 

  9. Weinbach, E. C., and Garbus, J., J. Biol. Chem., 241, 169 (1966).

    PubMed  CAS  Google Scholar 

  10. Weinbach, E. C., and Garbus, J., J. Biol. Chem., 241, 3708 (1966).

    PubMed  CAS  Google Scholar 

  11. Waterhouse, C., and Witter, R. F., Arch. Biochem. Biophys., 85, 1 (1959).

    Article  CAS  Google Scholar 

  12. Weinbach, E. C., J. Biol. Chem., 234, 1580 (1959).

    PubMed  CAS  Google Scholar 

  13. Beechey, R. B., Biochem. J., 98, 284 (1966).

    Article  CAS  Google Scholar 

  14. Helinski, D. R., and Cooper, C., J. Biol. Chem., 235, 3573 (1960).

    PubMed  CAS  Google Scholar 

  15. Ernster, L., in Kernicterus (edit. by Sass-Kortsak, A.), 174 (University of Toronto Press, 1961).

    Google Scholar 

  16. Hansch, C., Kiehs, K., and Lawrence, G. L., J. Amer. Chem. Soc., 87, 5770 (1965).

    Article  CAS  Google Scholar 

  17. Jongejans-Sickler, N. E., Kemp, A., and van Noordwijk, J., Biochem. Pharmacol., 6, 263 (1961).

    Article  CAS  Google Scholar 

  18. Starr, J. E., and Judis, J., J. Pharm. Sci., 57, 768 (1968).

    Article  CAS  Google Scholar 

  19. Grillo, M. A., and Cafiero, M., Biochim. Biophys. Acta, 82, 92 (1964).

    Article  CAS  Google Scholar 

  20. Moura-Goncalves, J., and Focesi, A., Nat. Cancer Inst. Monog., No. 27, 71 (1967).

  21. Wedding, R. T., Hansch, C., and Fukuto, T. R., Arch. Biochem. Biophys., 121, 9 (1967).

    Article  CAS  Google Scholar 

  22. Tata, J. R., Ernster, L., and Suranyi, E. M., Biochim. Biophys. Acta, 60, 461 (1962).

    Article  CAS  Google Scholar 

  23. Bowen, W. J., Martin, H. L., and Jacobus, W. E., Biochemistry, 4, 1936 (1965).

    Article  CAS  Google Scholar 

  24. Blum, J. J., and Sanadi, D. R., J. Biol. Chem., 239, 452 (1964).

    PubMed  CAS  Google Scholar 

  25. Weinbach, E. C., and Garbus, J., Biochem. J., 106, 711 (1968).

    Article  CAS  Google Scholar 

  26. Foster, J. F., in The Plasma Proteins, 1 (edit. by Putnam, F. W.), 179 (Academic Press, New York and London, 1960).

    Book  Google Scholar 

  27. Johnson, F. H., Eyring, H., and Polissar, M. J., The Kinetic Basis of Molecular Biology, 396 (John Wiley and Sons, New York, 1954).

    Google Scholar 

  28. Zalkin, H., and Racker, E., J. Biol. Chem., 240, 4017 (1965).

    CAS  Google Scholar 

  29. Whitehouse, M. W., and Skidmore, I. F., J. Pharm. Pharmacol., 17, 668 (1965).

    Article  CAS  Google Scholar 

  30. Markus, G., Proc. US Nat. Acad. Sci., 54, 253 (1965).

    Article  ADS  CAS  Google Scholar 

  31. Weinbach, E. C., and Bowen, W. J., Biochim. Biophys. Acta, 30, 4 6 (1958).

  32. Hackenbrock, C. R., J. Cell Biol., 30, 269 (1966).

    Article  CAS  Google Scholar 

  33. Green, D. E., Asai, J., Harris, R. A., and Penniston, J. T., Arch. Biochem. Biophys., 125, 684 (1968).

    Article  CAS  Google Scholar 

  34. Lehninger, A. L., Naturwissenschaften, 53, 57 (1966).

    Article  ADS  CAS  Google Scholar 

  35. Boyer, P. D., Oxidases and Related Redox Systems, 2 (edit. by King, T. E., Mason, H. S., and Morrison, M.), 994 (John Wiley and Sons, New York, London and Sydney, 1965).

    Google Scholar 

  36. Kaltenbach, J. C., and Harman, J. W., Exp. Cell Res., 8, 435 (1955).

    Article  CAS  Google Scholar 

  37. Lehninger, A. L., in Enzymes: Units of Biological Structure and Function (edit. by Gaebler, O. H.), 217 (Academic Press, New York, 1956).

    Google Scholar 

  38. King, T. E., Kuboyama, M., and Takemori, S., in Oxidases and Related Redox Systems, 2 (edit. by King, T. E., Mason, H. S., and Morrison, M.), 707 (Wiley, New York, 1965).

    Google Scholar 

  39. Rieske, J. S., Zaugg, W. S., and Hansen, R. E., J. Biol. Chem., 239, 3023 (1964).

    PubMed  CAS  Google Scholar 

  40. Weinbach, E. C., and Garbus, J., Biochim. Biophys. Acta., 162, 500 (1968).

    Article  CAS  Google Scholar 

  41. Edelman, G. M., and McClure, W. O., Accounts of Chemical Research, 1, 65 (1968).

    Article  CAS  Google Scholar 

  42. Hotchkiss, R. D., Adv. Enzymol., 4, 153 (1944).

    CAS  Google Scholar 

  43. Brody, T. M., and Bain, J. A., Proc. Soc. Exp. Biol. and Med., 77, 50 (1951).

    Article  CAS  Google Scholar 

  44. Zetterström, R., and Ernster, L., Nature, 178, 1335 (1956).

    Article  ADS  Google Scholar 

  45. Heytler, P. G., and Prichard, W. W., Biochem. Biophys. Res. Commun., 7, 272 (1962).

    Article  CAS  Google Scholar 

  46. Martins, C., and Nitz-Litzow, D., Biochim. Biophys. Acta, 12, 134 (1953).

    Article  Google Scholar 

  47. Weinbach, E. C., J. Biol. Chem., 210, 545 (1954).

    PubMed  CAS  Google Scholar 

  48. Hoch, F. L., and Lipmann, F., Proc. US Nat. Acad. Sci., 40, 909 (1954).

    Article  ADS  CAS  Google Scholar 

  49. Loomis, W. F., and Lipmann, F., J. Biol. Chem., 173, 807 (1948).

    CAS  Google Scholar 

  50. Abood, L. G., Proc. Soc. Exp. Biol. and Med., 88, 688 (1955).

    Article  CAS  Google Scholar 

  51. Whitehouse, M. W., and Haslam, J. M., Nature, 196, 1323 (1962).

    Article  ADS  CAS  Google Scholar 

  52. Runeberg, L., Biochem. Pharmacol., 11, 237 (1962).

    Article  CAS  Google Scholar 

  53. Gönnert, R., Johannis, J., Schraufstätter, E., and Strufe, R., Med. Chem. Abhandl. Med. Chem. Forschungsstätten Farbenfabriken Bayer, 7, 540 (1963).

    Google Scholar 

  54. Brody, T. M., J. Pharmacol. Exp. Therap., 113, 8 (1955).

    Google Scholar 

  55. Pressman, B. C., and Lardy, H. A., Biochim. Biophys. Acta, 21, 458 (1956).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

WEINBACH, E., GARBUS, J. Mechanism of Action of Reagents that uncouple Oxidative Phosphorylation. Nature 221, 1016–1018 (1969). https://doi.org/10.1038/2211016a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2211016a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing