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Spin-labelled Haemoglobin and the Haem–Haem Interaction

Nature volume 220, pages 787–788 (1968)Cite this article

Abstract

RECENT studies of the paramagnetic resonance of spin-labelled haemoglobin provide significant new information on the structural basis of the haem–haem interaction and on conformational changes linked to the spin state of the iron atoms (refs. 1 and 2 and our unpublished results). It is appropriate to summarize here some conclusions based on these studies, because Bretscher3 has recently concluded that (a) the spin state of the iron atom does not play a trigger part in the conformational changes associated with the haem–haem interaction, and (b) the conformational changes detected at cysteine (β93 by spin-labels are not necessarily related to the mechanism of the haem–haem interaction.

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References

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Authors and Affiliations

  1. Stauffer Laboratory for Physical Chemistry, Stanford, California

    H. M. McCONNELL, S. OGAWA & A. HORWITZ

Authors
  1. H. M. McCONNELL
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  2. S. OGAWA
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  3. A. HORWITZ
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McCONNELL, H., OGAWA, S. & HORWITZ, A. Spin-labelled Haemoglobin and the Haem–Haem Interaction. Nature 220, 787–788 (1968). https://doi.org/10.1038/220787a0

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