Abstract
SPECIFIC antigen markedly inhibits the migration of macrophages from tissue explants of animals which show positive delayed hypersensitivity skin tests to that antigen1,2. The technique of migration inhibition from capillary tubes introduced by George and Vaughan3 and extended by David et al.4,5 is the most practical. David6 and Bloom and Bennett7,8 have shown that the capillary-tube-migration-inhibition assay requires : (1) a non-sensitive, migrating macrophage cell population, usually obtained as peritoneal exudate cells induced by oil; (2) a sensitive lymphocyte cell population; and (3) specific antigen. A migration inhibition factor (MIF) is apparently synthesized and released by the hypersensitive lymphocytes after contact with antigen6–8. Normal cells cannot be sensitized by incubation with antigen alone, nor by incubating them with sera from animals previously shown to exhibit delayed hypersensitivity to the antigen.
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References
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THOR, D., JUREZIZ, R., VEACH, S. et al. Cell Migration Inhibition Factor released by Antigen from Human Peripheral Lymphocytes. Nature 219, 755–757 (1968). https://doi.org/10.1038/219755a0
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DOI: https://doi.org/10.1038/219755a0
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