Abstract
IT was shown earlier1 that an R factor determining resistance to kanamycin is spontaneously eliminated at 42° C, and its conjugal transfer is inhibited at this temperature. This temperature sensitivity was ascribed to temperature sensitive replication of the R factor. We present here evidence that the growth of cells is also inhibited at higher temperatures as a result of the presence of the temperature sensitive R factor.
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References
Terawaki, Y., Takayasu, H., and Akiba, T., J. Bact., 94, 687 (1967).
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Jacob, F., Brenner, S., and Cuzin, F., Cold Spring Harbor Symp. Quant. Biol., 28, 329 (1963).
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TERAWAKI, Y., KAKIZAWA, Y., TAKAYASU, H. et al. Temperature Sensitivity of Cell Growth in Escherichia coli associated with the Temperature Sensitive R(KM) Factor. Nature 219, 284–285 (1968). https://doi.org/10.1038/219284a0
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DOI: https://doi.org/10.1038/219284a0
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