Abstract
MANY authors1–5 consider that the insoluble, fluorescent pigments originating from oxidized unsaturated lipids are primary or secondary factors in the onset and evolution of several diseases, and vitamin E deficiency in man and animals is frequently associated with ceroid pigment1,5–8. In 1961, Geer et al.9 observed dense cytoplasmic inclusions in electron micrographs of atherosclerotic lesions and coronary endothelial cells. The inclusions had a dense core and showed knife striations; during processing they often shattered or dropped out of the section. Geer et al. suggested that these might be some form of hard material. Györkey et al.10 have observed crystalline structures similar to those to be described here in electron micrographs of ceroid isolated from human arteries.
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GONZALEZ, E. Insoluble Hard Material found in Human Atherosclerotic Aortas. Nature 219, 274–276 (1968). https://doi.org/10.1038/219274a0
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DOI: https://doi.org/10.1038/219274a0
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