Abstract
THE structures of several transfer RNAs from yeast and E. coli have recently been determined1–8. Although their sequences differ widely, they have some interesting features in common. They all conform to the clover-leaf model1 with the same numbers of nucleotides in the base-paired regions. In the five known structures of yeast transfer RNAs certain minor bases, when present, occur at identical sites. For example, 1–methylguanine and N2–methylguanine always occupy positions 9 and 10, respectively, from the 5′ end; 1–methyladenine occupies position 19 from the 3′–adenosine end and N2–dimethylguanine lies between the dihydrouridine-containing and anticodon loops. Because the primary structure of tyrosine tRNA from E. coli7 differs from that of yeast tyrosine tRNA3, it seemed of interest to compare the structure of a yeast transfer RNA with that of a mammalian one.
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STAEHELIN, M., ROGG, H., BAGULEY, B. et al. Structure of a Mammalian Serine tRNA. Nature 219, 1363–1365 (1968). https://doi.org/10.1038/2191363a0
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DOI: https://doi.org/10.1038/2191363a0
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