Abstract
ANAEROBIC glycolysis of washed human spermatozoa is inhibited by incubation with ABO isoantibodies when semen donors are of A or B secretor phenotype1. If this differential is related to the fertilizing capacity of affected cells2–3, a bias would be expected in the transmission of the A and B genes in the population. On this basis and on the basis of other data on fertility in the ABO system4–10, a mechanism which could account for the stability of the ABO polymorphism in terms of natural selection against gametes and intrauterine zygotes has been proposed11.
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References
Ackerman, D. R., Nature, 213, 253 (1967).
Davis, M. E., and McCune, W. W., Fertil. Steril, 1, 362 (1950).
Birnberg, C. H., Sherber, D. A., and Kurzrok, R. L., Amer. J. Obstet. Gynec., 63, 877 (1952).
Chung, C. S., and Morton, N., Amer. J. Hum. Genet., 13, 9 (1961).
Edwards, R. G., Ferguson, L. C., and Coombs, R. R. A., J. Reprod. Fertil., 7, 153 (1964).
Gershowitz, H., Behrman, S. J., and Neel, J., Science, 128, 719 (1958).
Heglar, R., Intern. J. Fertil., 7, 321 (1962).
Solish, G., Gershowitz, H., and Behrman, S. J., Proc. Soc. Exp. Biol. and Med., 108, 645 (1961).
Vos, G. H., and Kirk, R., J. Immunol., 80, 149 (1958).
McNeil, C., Trentleman, E., Fullmer, C., Kreutzer, V., and Orlob, R., Amer. J. Clin. Pathol., 28, 469 (1957).
Ackerman, D. R., Acta Genet. Stat. Med. (in the press).
Barker, S. B., and Summerson, W. H., J. Biol. Chem., 138, 535 (1941).
Matsunaga, Ei., and Hiraizumi, Y., Science, 135, 432 (1962).
Behrman, S. J., Buettner-Janusch, J., Heglar, R., Gershowitz, H., and Tew, W., Amer. J. Obstet. Gynec., 79, 847 (1960).
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ACKERMAN, D. Antibodies of the ABO System and the Metabolism of Human Spermatozoa: Metabolic Changes induced by Cooling and Freezing. Nature 219, 1159–1160 (1968). https://doi.org/10.1038/2191159a0
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DOI: https://doi.org/10.1038/2191159a0
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