Abstract
THE cytotoxic action of the difunctional alkylating agent mustard gas, di-(2-chloroethyl) sulphide, on mammalian cells has been clearly associated with its ability to interact with DNA. At low concentrations of the agent, the only detectable biochemical effect of this reaction is the inhibition of DNA synthesis1,2.
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References
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ROBERTS, J., CRATHORN, A. & BRENT, T. Repair of Alkylated DNA in Mammalian Cells. Nature 218, 970–972 (1968). https://doi.org/10.1038/218970a0
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DOI: https://doi.org/10.1038/218970a0
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