Abstract
THERE is abundant evidence that the sarcoplasmic reticulum (SR) of skeletal muscle plays an important part in excitation–contraction coupling and in relaxation of muscle fibres1. It is usually accepted that the ability of this membrane system to transport calcium ions rapidly in the immediate vicinity of the contractile proteins accounts for its effects. Thus release of calcium from SR to myofilaments leads to muscle contraction; removal and sequestration of calcium by the reticulum bring about relaxation.
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FANBURG, B., DRACHMAN, D., MOLL, D. et al. Calcium Transport in Isolated Sarcoplasmic Reticulum during Muscle Maturation. Nature 218, 962–964 (1968). https://doi.org/10.1038/218962a0
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DOI: https://doi.org/10.1038/218962a0
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