Abstract
THE pathogenesis of many parasitic diseases depends on the dynamics of the parasite population within the host. In schistosomiasis mansoni involving the liver, the eggs of the parasite are the chief pathogenetic agents1. The rate of reaction of the host to the eggs varies with its immune status2, and possibly the rate of egg destruction by the host also varies. In order to investigate this process it was necessary to know the age of schistosome eggs in the host. Methods previously used have been the stage of miracidial development3,4 (but this only serves for the first 6 days after laying) and reactive granuloma size (but this cannot be used for studies of host reaction, for it would involve circular reasoning).
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References
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BRADLEY, D. Labelling an Age-cohort of Eggs of Schistosoma mansoni in vivo. Nature 218, 776–777 (1968). https://doi.org/10.1038/218776b0
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DOI: https://doi.org/10.1038/218776b0
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