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Macroanionic Inhibition of Peptic Activity by High and Low Molecular Weight Macroanions

Nature volume 218, pages 770–771 (1968)Cite this article

Abstract

MACROANIONIC inhibition of peptic activity has been shown1 to be a result of substrate-inhibitor interaction, and is therefore a special case of macroanionic inhibition, a term2 normally implying inhibition following interaction with the enzyme which is behaving as a macrocation. A complementary case is the macrocationic inhibition of pepsin by polylysine3. The characteristics of macroanionic inhibition of peptic activity fall into two groups: those displayed by high molecular weight macroanions (HMW) on the one hand, and those of low molecular weight (LMW) on the other. This differentiation derives from the different structures of the substrate-inhibitor complexes formed by the two groups. The present purpose is to describe such differences and relate them to the observed differences in inhibition.

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Authors and Affiliations

  1. Department of Pharmacy, University of Strathclyde,

    A. J. BAILLIE & W. ANDERSON

Authors
  1. A. J. BAILLIE
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  2. W. ANDERSON
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BAILLIE, A., ANDERSON, W. Macroanionic Inhibition of Peptic Activity by High and Low Molecular Weight Macroanions. Nature 218, 770–771 (1968). https://doi.org/10.1038/218770a0

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  • DOI: https://doi.org/10.1038/218770a0

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