Abstract
ADENOSINE diphosphate (ADP) or adenosine triphosphate (ATP) injected intramuscularly or infused intravenously into rabbits reduces platelet adhesiveness measured on glass bead columns1. Furthermore, ADP inhibits the thrombocytopenia induced in rabbits by intravenous injections of collagen or thrombin2. It seemed worthwhile to determine whether similar effects could be obtained by releasing into the blood stream some of the body's stores of these nucleotides. Erythrocytes contain appreciable concentrations of ADP and ATP, so we decided to produce haemolysis in the rabbit by the intravenous infusion of water, and to study its effects on platelet behaviour. Platelet adhesiveness was reduced, and the thrombocytopenic activities of collagen and thrombin were much inhibited.
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References
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BUSFIELD, D., TOMICH, E. Acute Intravascular Haemolysis and Platelet Behaviour. Nature 218, 696–697 (1968). https://doi.org/10.1038/218696a0
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DOI: https://doi.org/10.1038/218696a0
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