Abstract
THERE is considerable evidence to indicate that, in the mouse, the immediate precursor of the antibody-forming cell is derived from an antigen-insensitive stem cell present in bone marrow1–3. Following immunization with sheep erythrocytes (SRBC), such precursor cells normally proliferate and differentiate giving rise to specific antibody-forming progeny4–6.
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References
Makinodan, T., Gengozian, N., and Congden, C. C., J. Immunol., 77, 250 (1956).
Doria, G., and Agarossi, G., Proc. US Nat. Acad. Sci., 58, 1366 (1967).
Mitchell, G. F., and Miller, J. F. A. P., Proc. US Nat. Acad. Sci., 59, 296 (1968).
Kennedy, J. C., Siminovitch, L., Till, J. E., and McCulloch, E. A., Proc. Soc. Exp. Biol. and Med., 120, 868 (1965).
Claflin, A. J., and Smithies, O., Science, 157, 1561 (1967).
Robinson, W. A., Marbrook, J., and Diener, E., J. Exp. Med., 126, 347 (1967).
Davies, A. J. S., Leuchars, E., Wallis, V., and Koller, P. C., Transplantation, 4, 438 (1966).
Davies, A. J. S., Leuchars, E., Wallis, V., Marchant, R., and Elliot, E. V., Transplantation, 5, 222 (1967).
Parrot, D. M. V., and de Sousa, M. A. B., Immunology, 13, 193 (1967).
Jerne, N. K., Nordin, A. A., and Henry, C., in Cell Bound Antibodies, 109 (Wistar Institute Press, Philadelphia, 1963).
Sterzl, J., and R̆íha, I., Nature, 208, 858 (1965).
Wortis, H. H., Taylor, R. B., and Dresser, D. W., Immunology, 11, 603 (1966).
Friedman, H., Proc. Soc. Exp. Biol. and Med., 117, 526 (1964).
Biozzi, G., Stiffel, C., Mouton, D., Bouthillier, Y., and Decreusefond, C-, Immunology, 14, 7 (1968).
Kennedy, J. C., Till, J. E., Siminovitch, L., and McCulloch, E. A., J. Immunol., 96, 973 (1966).
Wigzell, H., J. Exp. Med., 124, 953 (1966).
Celada, F., and Wigzell, H., Immunology, 11, 453 (1966).
Young, I., and Friedman, H., in Germinal Centres in Immune Responses, 102 (Springer Verlag, New York, 1967).
Kind, P., and Campbell, P. A., J. Immunol., 100, 55 (1968).
Celada, F., J. Exp. Med., 125, 199 (1967).
Bussard, A. E., and Lurie, M., J. Exp. Med., 125, 873 (1967).
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GREGORY, C., LAJTHA, L. Kinetic Study of the Production of Antibody-forming Cells from their Precursors. Nature 218, 1079–1081 (1968). https://doi.org/10.1038/2181079a0
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DOI: https://doi.org/10.1038/2181079a0
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