Abstract
Barbiturates form strong, specific hydrogen bonds with derivatives of adenine. This highly specific interaction which is more extensive than the hydrogen bonding between thymine (or uracil) derivatives and adenine derivatives may help to explain the different biological effects of barbiturates.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Sharpless, S. K., in The Pharmacological Basis of Therapeutics (edit. by Goodman, L. S., and Gilman, A.), 105 (Macmillan Co., New York, 1965).
Hamlin, jun., R. M., Lord, R. C., and Rich, A., Science, 148, 1734 (1965).
Küchler, E., and Derkosch, J., Z. Naturforsch., 21B, 209 (1966).
Kyogoku, Y., Lord, R. C., and Rich, A., J. Amer. Chem. Soc., 89, 496 (1967).
Kyogoku, Y., Lord, R. C., and Rich, A., Science, 154, 518 (1966).
Pitha, J., Jones, R. N., and Pithova, P., Canad. J. Chem., 44, 1045 (1966).
Katz, L., and Penman, S., J. Mol. Biol., 15, 220 (1966).
Shoup, R. R., Miles, H. T., and Becker, E. D., Biochim. Biophys. Res. Commun., 23, 194 (1966).
Kyogoku, Y., Lord, R. C., and Rich, A., Proc. US Nat. Acad. Sci., 57, 250 (1967).
Hoogsteen, K., Acta Cryst., 16, 907 (1963).
Mathews, F. S., and Rich, A., J. Mol. Biol., 8, 89 (1964).
Katz, L., Tomita, K., and Rich, A., J. Mol. Biol., 13, 340 (1965).
Haschemeyer, A. E. V., and Sobell, H. M., Nature, 202, 969 (1964).
O'Brien, E. J., J. Mol. Biol., 7, 107 (1963).
Bush, M. T., in Physiological Pharmacology (edit. by Root, W. S., and Hoffmann, F. G.), 1, 185 (Academic Press, New York, 1963).
Hansen, R. L., Phys. Chem., 66, 369 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KYOGOKU, Y., LORD, R. & RICH, A. Specific Hydrogen Bonding of Barbiturates to Adenine Derivatives. Nature 218, 69–72 (1968). https://doi.org/10.1038/218069a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/218069a0
This article is cited by
-
Structures and energies of seleno derivatives of biuret.Ab Initio comparative studies of diselenobiuret, selenobiuret, and selenothiobiuret
Structural Chemistry (1997)
-
Synthesis, complexing properties and molecular modelling of open chain receptors of barbiturates derived from 2,6-diamino pyridine
Journal of Inclusion Phenomena and Molecular Recognition in Chemistry (1994)
-
Effects of pentobarbital tolerance to and dependence on GABAB receptor binding
Neurochemical Research (1991)
-
Interaction between barbiturate and membrane components
Archives of Pharmacal Research (1990)
-
Improvement of barbiturate gas chromatography by formic acid: Possible mechanism
Chromatographia (1974)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
