Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Genetics and Cultural Properties of Mutants of Salmonella typhimurium lacking Glucosyl or Galactosyl Lipopolysaccharide Transferases

Nature volume 217, pages 955–957 (1968)Cite this article

Abstract

THE somatic (0) lipopolysaccharide of smooth salmonella strains contains an inner part or core, believed to be the same in all species; this consists of a heptose-containing “backbone”, with short side-chains which contain glucose, galactose and N-acetylglucosamine and are thought to have the structure shown in Fig. 1 (ref. 1). The outer, O-specific part of lipopolysaccharide (absent in rough strains) is made up of many repeat units of an oligosaccharide the composition of which determines the O antigens of the strain. These O-specific chains are probably attached to the distal ends of the core side-chains. This and the following communication describe mutants in glycosyl-transferring enzymes concerned in the biosynthesis of the side-chains of the core.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Lüderitz, O., Staub, A. M., and Westphal, O., Bact. Rev., 30, 192 (1966).

    PubMed  PubMed Central  Google Scholar 

  2. Fukasawa, T., and Nikaido, H., Genetics, 46, 1295 (1961).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Nikaido, H., Proc. US Nat. Acad. Sci., 48, 1337 (1962).

    Article  ADS  CAS  Google Scholar 

  4. Nikaido, H., Proc. US Nat. Acad. Sci., 48, 1542 (1962).

    Article  ADS  CAS  Google Scholar 

  5. Osborn, M. J., Rosen, S. M., Rothfield, L., and Horecker, B. L., Proc. US Nat. Acad. Sci., 48, 1831 (1962).

    Article  ADS  CAS  Google Scholar 

  6. Subbaiah, T. V., and Stocker, B. A. D., Nature, 201, 1298 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Naide, Y., Nikaido, H., Mäkelä, P. H., Wilkinson, R. G., and Stocker, B. A. D., Proc. US Nat. Acad. Sci., 53, 147 (1965).

    Article  ADS  CAS  Google Scholar 

  8. Shedlovsky, A., and Brenner, S., Proc. US Nat. Acad. Sci., 50, 300 (1963).

    Article  ADS  CAS  Google Scholar 

  9. Felix, A., and Callow, B. R., Brit. Med. J., ii, 127 (1943).

  10. Kay, D., J. Gen. Microbiol., 27, 201 (1962).

    Article  CAS  PubMed  Google Scholar 

  11. Rosen, S. M., Zeleznick, L. D., Fraenkel, D., Wiener, I. M., Osborn, M. J., and Horecker, B. L., Biochem. Z., 342, 375 (1965).

    CAS  PubMed  Google Scholar 

  12. Levine, M., Virology, 3, 22 (1957).

    Article  CAS  PubMed  Google Scholar 

  13. Yamamoto, N., and Anderson, T. F., Virology, 14, 430 (1961).

    Article  CAS  PubMed  Google Scholar 

  14. Brandis, H., Z. Bakt. Parasitkde, I (Orig.), 165, 305 (1956).

    CAS  Google Scholar 

  15. Brandis, H., Z. Bakt. Parasitkde, I (Orig.), 199, 185 (1966).

    CAS  Google Scholar 

  16. Sanderson, K. E., and Demerec, M., Genetics, 51, 896 (1965).

    Google Scholar 

  17. Zinder, N. D., Science, 131, 924 (1960).

    Article  ADS  CAS  PubMed  Google Scholar 

  18. Demerec, M., Adelberg, E. A., Clark, A. J., and Hartman, P. E., Genetics, 54, 61 (1966).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Author notes

  1. R. G. WILKINSON

    Present address: Department of Physiological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland

  2. B. A. D. STOCKER

    Present address: Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California

Authors and Affiliations

  1. Guinness–Lister Research Unit, Lister Institute of Preventive Medicine, Chelsea Bridge Road, London, SW1.

    R. G. WILKINSON & B. A. D. STOCKER

Authors
  1. R. G. WILKINSON
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. A. D. STOCKER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

WILKINSON, R., STOCKER, B. Genetics and Cultural Properties of Mutants of Salmonella typhimurium lacking Glucosyl or Galactosyl Lipopolysaccharide Transferases. Nature 217, 955–957 (1968). https://doi.org/10.1038/217955a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/217955a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing