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Combined Inhibition of Influenza Virus Reproduction in Cell Culture using Interferon and Amantadine

Nature volume 217, pages 856–857 (1968)Cite this article

Abstract

AMANTADINE hydrochloride is the first synthetic ariti-influenza compound which has been successfully tested in human beings1,2. Results of an investigation showed that none of its derivatives was more effective than amantadine itself. Thus attempts to increase the antiviral prophylactic activity of amantadine and to reduce its dosage in order to diminish the toxicity3 are necessary.

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Authors and Affiliations

  1. D. I. Ivanovsky Institute of Virology, Academy of Medical Sciences, Moscow

    S. V. LAVROV, E. I. EREMKINA, T. G. ORLOVA, G. A. GALEGOV, V. D. SOLOVIEV & V. M. ZHDANOV

  2. N. F. Gamaleya Institute of Epidemiology and Microbiology, Moscow

    S. V. LAVROV, E. I. EREMKINA, T. G. ORLOVA, G. A. GALEGOV, V. D. SOLOVIEV & V. M. ZHDANOV

Authors
  1. S. V. LAVROV
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  2. E. I. EREMKINA
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  3. T. G. ORLOVA
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  4. G. A. GALEGOV
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  5. V. D. SOLOVIEV
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  6. V. M. ZHDANOV
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LAVROV, S., EREMKINA, E., ORLOVA, T. et al. Combined Inhibition of Influenza Virus Reproduction in Cell Culture using Interferon and Amantadine. Nature 217, 856–857 (1968). https://doi.org/10.1038/217856a0

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